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News| Complementarity-determining Region Clustering May Cause CAR-T Cell Dysfunction

News| Complementarity-determining Region Clustering May Cause CAR-T Cell Dysfunction

2025-01-09
A recent study published in Nature Communications on August 13, 2023, reveals that the complementarity determining region (CDR) loop in a single chain variable fragment (scFv) can induce CAR aggregation, leading to significant issues in chimeric antigen receptor (CAR)-T cell therapy. Researchers found that this aggregation causes CAR-T cell failure, cell death, and decreased tumor cell reactivity towards targeted antigens. This results in antigen-independent activation and potential functional impairment of the CAR-T cells. The implications of this research highlight critical challenges in enhancing the efficacy of CAR-T cell therapies, a focus of ongoing investigation in the field, particularly for companies like Alpha Lifetech Incorporation, which is dedicated to advancing CAR technology.
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Sanger Sequencing vs. Next-Generation Sequencing (NGS)

Sanger Sequencing vs. Next-Generation Sequencing (NGS)

2024-11-27

Alpha Lifetech Incorporation is revolutionizing the field of biotechnology by offering comprehensive upstream and downstream services tailored for recombinant proteins. With a focus on delivering high-quality protein resources, Alpha Lifetech aims to streamline research and development processes for biopharmaceutical companies. By providing innovative solutions that cater to the industry's specific needs, the company ensures efficient production and purification of proteins. This initiative enhances the capabilities of scientists and researchers and positions Alpha Lifetech as a leader in the biotechnology sector. With a commitment to advancing protein technologies, Alpha Lifetech Incorporation is poised to make significant contributions to scientific breakthroughs and therapeutic developments.

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Comprehensive Guidelines to Protein Purification: Methods, Techniques, and Applications

Comprehensive Guidelines to Protein Purification: Methods, Techniques, and Applications

2024-10-30

Alpha Lifetech Incorporation has announced a comprehensive review of protein purification, an essential step in the protein production process. The review provides key insights and important points for subsequent experiments and research in the field of protein purification. This review is expected to significantly contribute to the advancement of protein production and development of new therapeutic targets. Alpha Lifetech Incorporation is known for its expertise in biopharmaceutical manufacturing and is committed to providing cutting-edge solutions for protein purification. This review is anticipated to have a major impact on the industry and solidify Alpha Lifetech's position as a leader in biopharmaceutical research and development.

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Latest News| New Research Shows Potential to Reverse Cancer Wasting

Latest News| New Research Shows Potential to Reverse Cancer Wasting

2024-09-27

On June 1, 2024, in the journal Nature Communications, scientists from Bo Li's research team published an article titled "Area postrema neurons mediate interleukin-6 function in cancer cachexia". The article found that sustained elevation of interleukin-6 can lead to brain dysfunction and ultimately cancer cachexia.

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Latest News | A First-In-Class Selective Inhibitor of EGFR and PI3K Offers A Single-Molecule Approach to Targeting Adaptive Resistance

Latest News | A First-In-Class Selective Inhibitor of EGFR and PI3K Offers A Single-Molecule Approach to Targeting Adaptive Resistance

2024-09-11

On July 11, 2024, a team of researchers led by Dr. Judith Sebolt Leopold designed a kinase inhibitor MTX-531 that can block epidermal growth factor receptor (EGFR) and phosphatidylinositol 3-OH kinase (PI3K).

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Accelerate Drug Discovery with Biosimilar Antibodies - The Fast Track to Target Binding

Accelerate Drug Discovery with Biosimilar Antibodies - The Fast Track to Target Binding

2024-04-30

Alpha Lifetech's 700+ biosimilar antibodies target EGFR, TNF-α, VEGF, speeding up drug research with validated quality.

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Unlocking the Mysteries of Biological Processes: Alpha Lifetech Produces High-Quality Membrane Proteins for Scientists

Unlocking the Mysteries of Biological Processes: Alpha Lifetech Produces High-Quality Membrane Proteins for Scientists

2024-04-30

Alpha Lifetech offers quality membrane proteins for drug discovery and cellular insights, using advanced production techniques.

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The Art and Science of Nanobody Discovery: How Alpha Lifetech is Pushing Boundaries

The Art and Science of Nanobody Discovery: How Alpha Lifetech is Pushing Boundaries

2024-04-29

Discover nanobody technology: phage display, immunization, screening, selection, and structural analysis at Alpha Lifetech for diagnostics and therapy.

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