Phage Display Peptide Library Screening Platform
Alpha Lifetech has rich experience in peptide phage library construction and screening, providing strong technical support for small molecule drug discovery, clinical diagnosis,disease treatment and biological research. With highly educated and experienced researchers in phage display peptide library screening, we have been focusing on high-affinity peptide phage library construction and screening services for ten years, and have screened peptides with clinical applications for many customers around the world, of which more than 98% have high affinity and specificity, which has further contributed to the advancement of global biomedical field.
The peptides screened by phage display library technology have high affinity and can bind specifically to target proteins. In addition, the premade peptide library screening methods have the advantages of low production cost and short preparation cycle. The advantages of peptides, such as small molecules, high tissue permeability, high stability, low immunogenicity and toxicity, make them widely used in drug discovery, vaccine preparation, targeted diagnosis and treatment of cancer, cell signaling pathway research and other biomedical fields.
phage display peptide library types
Alpha Lifetech is dedicated to developing peptide display library construction and screening programs for our global customers to ensure that functionally important peptide sequences are screened within a specified time frame. We can provide linear peptide libraries, cyclic peptide libraries and other randomized peptide libraries containing 5-25 amino acids., and our peptide phage display libraries have a library capacity of more than 10^9, which is more conducive to the screening of ideal peptide sequences to meet the needs of our customers. Up to now, we have successfully constructed linear 7 peptide libraries, linear 9 peptide libraries, linear 10 peptide libraries, linear 15 peptide libraries, linear 12 peptide libraries, cyclic 7 peptide libraries, and other peptide libraries with different amino acid quantities and structures, in order to satisfy the different needs of scientists around the world.
Diversified phage peptide library
Our peptide library covers linear peptides, cyclic peptides, and modified peptides to ensure high coverage and diversity of targets. The library type is flexible and diverse, which can meet the needs of drug development, diagnostic marker discovery and functional peptide screening.
Intelligent screening process
Customize the screening strategy according to the characteristics of the target, combined with solid-phase screening, liquid-phase screening and cell screening to ensure high specificity and high affinity. Multiple rounds of screening and enrichment, accurate capture of high-value peptides.
Efficient verification and optimization
Using high-throughput sequencing and bioinformatics technology to quickly lock the target sequence, optimize the screening results, and save R & D time and cost.
Full-chain service support
Providing a one-stop solution from peptide library construction to subsequent verification to support downstream drug development and molecular mechanism research.
Phage Display Peptide Library Screening Process

Fig.1 Phage Display Peptide Library Screening Platform
Phage Display Peptide Library Screening Workflow
Process | Service Content | Timeline |
---|---|---|
1. Target Immobilization and Peptide Library Incubation | Target molecules ( such as proteins, antibodies or cells ) are immobilized on solid-phase carriers and incubated with phages in the peptide display library to bind specific peptides to the target. | 1 day |
2. Elution and Enrichment | The non-specific binding phages were removed by low pH elution and competitive molecular elution, and the phages with high affinity were enriched. | 1 day |
3. Screening Cycle | After 3-4 rounds of screening, the strictness of screening conditions was gradually improved, and the specificity of the selected peptides to the target was enhanced. | 1 week |
4. Peptide Sequence Analysis | The enriched phages were analyzed by high-throughput sequencing to mine the optimal peptide sequence. | 1 week |

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