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Recombinant Human CD137/TNFRSF9/4-1BB Protein, His Tag

Protein

Recombinant Human CD137/TNFRSF9/4-1BB Protein, His Tag

  • Expression Host: HEK293 Cells
  • Species: Human
  • Size: 50ug,100ug,500ug
  • Official Symbol: CD137

TNFRSF9 (TNF Receptor Superfamily Member 9) is a Protein Coding gene. Diseases associated with TNFRSF9 include Immunodeficiency 109 With Lymphoproliferation and B-Cell Lymphoma. Among its related pathways are Akt Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions. Gene Ontology (GO) annotations related to this gene include signaling receptor activity and cytokine binding. An important paralog of this gene is TNFRSF21.Receptor for TNFSF9/4-1BBL.Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable).

 

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Product Background

Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necrosis factor receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. CD137 is expressed by mesenchymal cells, including endothelial cells, chondrocytes, and cells of the central nervous system. CD137 is also broadly expressed by cells of the human immune system, is broadly expressed by cells of the human immune system, including activated CD8+ and CD4+ T cells, activated natural killer(NK) cells, follicular dendritic cells(FDCs) and monocytes. CD137 has diverse roles in the immune response, the one key function is to promote the survival of both T cells and dendritic cells by binding the cognate ligand CD137L(4-1BBL).

Product Specification

Catalog Number

ALP64693

Product Name

Recombinant Human CD137/TNFRSF9/4-1BB Protein, His Tag

Alias

CD137, ILA

Alternate Names

cd137,cd137 agonist,cd137 ligand,cd137 gene,human cd137,cd137 protein,tnfrsf9,tnfrsf9 gene,human tnfrsf9 elisa,human tnfrsf9,4-1bb,4-1bb ligand,4-1bb gene,4-1bb agonist,human 4-1bb elisa,human 4-1bb ligand,Recombinant Protein,Human CD137 Protein,Human tnfrsf9 Protein,his tag,his tag protein

Official Symbol

CD137/TNFRSF9/4-1BB

Species

Human

Expression Host

HEK293 Cells

Protein Family

TNF-receptor Superfamily

Product Description

ALP64693 Recombinant Human CD137 Protein, His Tag is produced in HEK293 Cells and the target gene encoding Leu24-Gln186 is expressed with a 6His tag at the C-terminus.

Size

50ug,100ug,500ug

Purification

Affinity Purification

Purity

>90%-95% as determined by SDS-PAGE

Endotoxin

<1.0 EU/ug determined by the LAL method

Buffer

Supplied in PBS, pH7.4

Storage

For long term storage, store the reagent at -80°C. Avoid repeated freeze-thaw cycles.

Shipping Condition

Lyophilized powder is shipped at ambient temperature. Liquid form is shipped in dry ice.

Note

This product is for research use only. This product can not be used for human.

Reference

1 Watts, T. H., Annual Review of Immunology, 2005, DOI: 10.1146/annurev.immunol.23.021704.115839

2 Melero, I., Shuford, W. W., Newby, S. A., Aruffo, A., Ledbetter, J. A., Hellström, K. E., Mittler, R. S., Chen, L., Nature Medicine, 1997, DOI: 10.1038/nm0597-682

3 Vinay, D. S., Kwon, B. S., Molecular Cancer Therapeutics, 2012, DOI: 10.1158/1535-7163.MCT-11-0970

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