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Immunology
What is immunology?
Immunology is a discipline that studies the immune system and is a very important branch of medicine and biological sciences. Immunology is a relatively new science. Its origin is usually attributed to Edward Jenner, who discovered in 1796 that cowpox or vaccinia can prevent smallpox in humans, a usually fatal disease. Jenner referred to his program as vaccination, a term still used to describe healthy individuals receiving a weakened or attenuated strain of a pathogen to provide disease protection.
What Is the Content of Immunological Research?
Why Is Immunology Important?
Innate Immune System
Immune System fights against microbes and prevent their entry inside the body. Innate Immune System is composed of cells and proteins that are always present and are ready to fight against microbes in the infection area. Innate Immune System is present from the time of our birth.
Components of Innate Immunity | Function | |
---|---|---|
1 | Epithelial cells | Act as barrier to infection |
2 | Complement proteins | Circulating proteins that can induce a variety of inflammatory response to pathogens |
Select Cells of Innate Immunity | Function | |
1 | Monocytes | May differentiated into macrophages or monocytes in response to infection, neoplastic disease, or inflammation |
2 | Macrophages | Migrates from blood vessels into tissues, consumption of pathogens and cancerous cells by phagocytosis, may present antigens to activate the adaptive immune response |
3 | Dendritic cell | Presents antigens on its surface resulting in activation of the adaptive immune response |
4 | Neutrophils | Represent 50%–60% of circulating leukocytes, release products to kill pathogens, stimulate immune response |
5 | Natural killer cell | Possess cell-killing ability, can destroy tumor cells and cells infected with viruses |
Adaptive Immune System
Types of Lymphocytes |
Function | |
---|---|---|
1 | B lymphocyte | Production of antibodies, neutralization of microbes, facilitates phagocytosis |
2 | Helper CD4+ T lymphocyte | Activates a variety of other cell types (B lymphocytes, other T lymphocytes, including cytotoxic T lymphocytes, macrophages) and mediates inflammatory response |
3 | Cytotoxic CD81 T lymphocyte | Kills infected or neoplastic cells |
4 | Regulatory T lymphocytes (regulatory T cells) | This is a subset of CD41 lymphocytes that inhibits the immune response |