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RESEARCH AREAS

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Cancer
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Cell Biology
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Metabolism
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Immunology

Metabolism

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What is Metabolism?

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Metabolism is a biotransformation process, where endogenous and exogenous compounds are converted to more polar products to facilitate their elimination from the body .

No matter what you 're doing, your body is always working and using energy. This energy comes from the food and drinks you consume. Your metabolism controls how much of that energy your body uses. 
It's a complex process that combines calories and oxygen to create and release energy. This energy fuels body functions. 

What are the factors that affect our metabolism?

A variety of factors influence our metabolism, including genes, diet, sleep, exercise, and more. Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic demand.

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Research progress of various cellular metabolic mechanisms


In a review the author summarizes the historical understanding of one-carbon metabolism in cancer, describes the recent findings regarding the generation and usage of one-carbon units and explores possible future therapeutics that could exploit the dependency of cancer cells on one-carbon metabolism. Oncogenic signalling and metabolic alterations are interrelated in cancer cells, mTOR, which is frequently activated in cancer, controls cell growth and metabolism. Cellular metabolism has emerged as a critical determinant of the viability and function of both cancer cells and immune cells. This Review discusses current understanding of adaptive and innate immune cell metabolism in the context of the tumor microenvironment, providing insight into the interaction of cancer cell metabolism and immune metabolism, as well as the potential for leveraging metabolic vulnerabilities to enhance the anti-tumor immune response.

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Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a common feature of all cancers, requires fatty acids for synthesis of membranes and signaling molecules. Cancer cells frequently display fundamentally altered cellular metabolism, which provides the biochemical foundation and directly contributes to tumorigenicity and malignancy. Another Review summarizes past and recent advances in our understanding of the reprogramming of glucose metabolism in cancer cells, which is mediated by oncogenic drivers and by the undifferentiated character of cancer cells. The reprogrammed glucose metabolism in cancer cells is required to fulfil anabolic demands. Metabolic reprogramming contributes to tumor development and introduces metabolic liabilities that can be exploited to treat cancer.

Reference
ALMAZROO O A, MIAH M K, VENKATARAMANAN R. Drug Metabolism in the Liver [J]. Clinics in Liver Disease, 2017, 21(1): 1-+.
GOODPASTER B H, SPARKS L M. Metabolic Flexibility in Health and Disease [J]. Cell Metabolism, 2017, 25(5): 1027-36.
NEWMAN A C, MADDOCKS O D K. One-carbon metabolism in cancer [J]. British Journal of Cancer, 2017, 116(12): 1499-504.
MOSSMANN D, PARK S, HALL M N. mTOR signalling and cellular metabolism are mutual determinants in cancer [J]. Nature Reviews Cancer, 2018, 18(12): 744-57.
LEONE R D, POWELL J D. Metabolism of immune cells in cancer [J]. Nature Reviews Cancer, 2020, 20(9): 516-31.
VANDER HEIDEN M G, DEBERARDINIS R J. Understanding the Intersections between Metabolism and Cancer Biology [J]. Cell, 2017, 168(4): 
CURRIE E, SCHULZE A, ZECHNER R, et al. Cellular Fatty Acid Metabolism and Cancer [J]. Cell Metabolism, 2013, 18(2): 153-61.
LUO X J, CHENG C, TAN Z Q, et al. Emerging roles of lipid metabolism in cancer metastasis [J]. Molecular Cancer, 2017, 16(
HAY N. Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? [J]. Nature Reviews Cancer, 2016, 16(10): 635-49.
LUENGO A, GUI D Y, VANDER HEIDEN M G. Targeting Metabolism for Cancer Therapy [J]. Cell Chemical Biology, 2017, 24(9): 1161-80.