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ADT1007-Abituzumab Biosimilar (ITGAV/CD5)-Research Biosimilar Antibody
Antibody

ADT1007-Abituzumab Biosimilar (ITGAV/CD5)-Research Biosimilar Antibody

  • Catalog Number ADT1007
  • Host CHO Cells
  • Species Human
  • Target ITGAV /CD51
  • Application Inhibition, Agonist, ELISA, FACS, Functional Assay

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Product Background

ITGAV (αV) and ITGB3 (β3) form the heterodimeric integrin αVβ3, a transmembrane receptor with: Extracellular Domains: The αV subunit contains a β-propeller domain for ligand binding, while β3 includes an I-like domain. Together, they recognize RGD (Arg-Gly-Asp) motifs in ligands like vitronectin, fibronectin, and osteopontin. Transmembrane Helices: Anchor the receptor in the plasma membrane. Cytoplasmic Tails: Interact with cytoskeletal proteins (e.g., talin, vinculin) and signaling molecules (e.g., FAK, Src). αVβ3 exists in bent (inactive) and extended (active) conformations, regulated by inside-out (intracellular signals) and outside-in (ligand binding) signaling.

Product Specification

Catalog Number

ADT1007

Product Name

ADT1007-Abituzumab Biosimilar (ITGAV/CD5)-Research Biosimilar Antibody

Clonity

Monoclonal

Alternate Names

itgav antibody,  cd51 antibody,  itgav blocking antibody,  cd51 blocking antibodies,  anti-mouse cd51 antibody,  anti-cd51 antibody,  anti cd51 antibody,  recombinant cd51,  anti-cd51 monoclonal antibody,  cd51 antibodies,  cd51 recombinant antibody,  itgav recombinant antibody

Alias

DI-17E6,  EMD 525797, ITGAV, CD51, anti-ITGAV

Host

CHO Cells

Species

Human

Target

ITGAV /CD51

Gene ID

3685

Isotype

IgG2 Kappa

Size

100ug, 1mg, 5mg

Research Area

Cancer

CAS Number

1105038-73-0

Product Description

Abituzumab is a humanized IgG2 monoclonal antibody (mAb) targeted at CD51 (an integrin) currently in development by Merck KGaA Darmstadt,  Germany in an attempt to prevent bone lesion metastases in castration-resistant prostate cancer.

Molecular Weight

144.58 kDa

Application

Inhibition,  Agonist, ELISA,  FACS,  Functional Assay

Purity

>95% as determined by SDS-PAGE

Concentration

batch dependent

Buffer

Supplied in PBS,  PH7.5

Storage

Store at -20 °C for 12 months. Store at -80 °C for long term storage.

Shipping Condition

Shipped on ice packs.

Note

This product is for research use only.

Reference

1. Tang YL,  et al. BMC Pulm Med,  2022 Aug 4. PMID 35927660
2. Fu T,  et al. Obes Facts,  2022. PMID 35320805
3. Kemper M,  et al. J Exp Clin Cancer Res,  2021 Jun 26. PMID 34174926