- +1 609-736-0910
- info@alphalifetech.com
- 90 State Street, STE 700 Office 40, Albany, NY 12207 United States
Product Background
Catalog Number |
ADT1012 |
Product Name |
Recombinant Human Biotinylated CD28 Protein, Fc Tag, Avi Tag |
Alias |
D2E7, Ig gamma-1 chain C region |
Isotype |
IgG1 Kappa |
Clonity |
Monoclonal |
|
Alternate Names tnf alpha, tnf alpha gene, tnf alpha pathway, mouse tnf alpha, anti tnf alpha, tnf-alpha protein, tnf alpha monoclonal antibody, human tnf alpha, anti-tnf-alpha therapy, tnfa gene
|
|
Official Symbol |
TNF alpha/TNFA/TNFSF2 |
Species |
Human |
Expression Host |
CHO Cells |
Research Area |
Immunology |
Product Description |
Adalimumab is a disease-modifying antirheumatic drug and monoclonal antibody that works by inactivating tumor necrosis factor-alpha. |
Mechanism of Action |
Adalimumab binds with specificity to tumor necrosis factor-alpha (TNF-alpha) and inhibits its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab also lyses surface tumor necrosis factor expressing cells in vitro when in the presence of complement. |
Metabolism |
Most likely removed by opsonization via the reticuloendothelial system. |
Gene ID |
7124 |
Size |
1mg,5mg |
CAS Number |
331731-18-1 |
Molecular Weight |
144KDa |
Chemical Formula |
C6428H9912N1694O1987S46 |
Application |
FC, IP, ELISA, Neut, Functional assay |
Purity |
>95% as determined by SDS-PAGE |
Concentration |
Batch dependent |
Buffer |
Supplied in PBS, PH7.5 |
Storage |
Store at -20 °C for 12 months. Store at -80 °C for long term storage. |
Shipping Condition |
Shipped on ice packs. |
Note |
This product is for research use only. |
Reactivity |
Human |
|
Reference 1.Nuber-Champier A, et al. Psychoneuroendocrinology, 2023 Jul. PMID 37104966
2.Sudershan A, et al. BMC Neurol, 2023 Apr 21. PMID 37085790
3.Lücke J, et al. Front Immunol, 2023. PMID 37063909
|
FAQ
-
+ -
What is a biosimilar?
A biosimilar is a biological product that is highly similar to an existing approved reference biological product (also known as the originator or reference product), with no clinically meaningful differences in terms of safety, purity, and potency. Biosimilars are developed to be highly similar to the reference product in terms of structure, function, pharmacokinetics, and clinical efficacy. Alpha Lifetech can provide biosimilar antibody products.
-
+ -
How can I obtain COA of the reagent that I received?
Please contact us via email info@alphalifetech.com for detailed information about the product.
-
+ -
Why choose Alpha Lifetech’s product?
Alpha Lifetech's products are chosen for their quality, reliability, and competitive pricing. Our biosimilar antibodies undergo thorough development and testing processes to ensure they meet regulatory requirements and deliver comparable performance to reference products. We prioritize customer satisfaction and strive to provide cost-effective solutions without compromising on quality. -
+ -
How to purify your antibodies?
Protein A/G Chromatography: Protein A and Protein G are affinity chromatography matrices that specifically bind to the Fc region of antibodies, allowing for their purification from complex mixtures.
Ion Exchange Chromatography: Ion exchange chromatography separates proteins based on their net charge at a specific pH.
Size Exclusion Chromatography: Size exclusion chromatography (SEC), also known as gel filtration chromatography, separates proteins based on their size and shape.
Affinity Tag Purification: Some recombinant antibodies are engineered with affinity tags (e.g., His-tag, FLAG-tag) that facilitate purification. Affinity tag purification involves using specific affinity resins or columns that bind to the tag, allowing for purification of the tagged antibodies. Alpha Lifetech has multiple antibody purification strategies. Please contact us via email info@alphalifetech.com for more detailed information.