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Product Background
Catalog Number |
ADT1015 |
Product Name |
ADT1015-Aducanumab Biosimilar– Anti-APP Abeta mAb – Research Grade |
Alias |
BART, BIIB-037 |
Isotype |
IgG1 Kappa |
Clonity |
Monoclonal |
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Alternate Names anti-APP antibody, APP antibody, amyloid precursor protein antibody, anti amyloid precursor protein antibody
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Official Symbol |
APP/Abeta |
Species |
Human |
Expression Host |
CHO Cells |
Reactivity |
Human |
Gene ID |
351 |
CAS Number |
1384260-65-4 |
Molecular Weight |
146.0 KDa |
Product Description |
Aducanumab, sold under the brand name Aduhelm, is a medication used to treat Alzheimer's disease (AD). It is an amyloid beta-directed monoclonal antibody. Aducanumab targets aggregated forms of Amyloid beta (Aβ) found in the brains of people with Alzheimer's disease to reduce its buildup. |
Mechanism of Action |
Alzheimer's disease is a neurodegenerative disease. Part of the pathology of Alzheimer's disease is the presence of plaques forming extracellularly in the brain. These plaques are mostly composed of amyloid-β, a peptide of varying length formed by the cleavage of the amyloid precursor protein. The "amyloid cascade hypothesis" suggests that the accumulation of amyloid-β oligopeptides in the brain drives the pathogenesis of Alzheimer's disease. |
Metabolism |
Aducanumab is expected to be broken down into smaller oligopeptides and amino acids. |
Size |
100ug,1mg,5mg |
Research Area |
Neurobiology |
Application |
Elisa, WB |
Purity |
>95% as determined by SDS-PAGE |
Concentration |
Batch dependent |
Buffer |
Supplied in PBS, PH7.5 |
Storage |
Store at -20 °C for 12 months. Store at -80 °C for long term storage. |
Shipping Condition |
Shipped on ice packs. |
Note |
This product is for research use only. |
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Reference 1.Poore AT, et al. Inorg Chem, 2023 Jul 10. PMID 37369063
2.Noguchi-Shinohara M, et al. Parkinsonism Relat Disord, 2023 Jun. PMID 37201326
3.Firouzi R, et al. Int J Mol Sci, 2023 May 3. PMID 37175868
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FAQ
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What is a biosimilar?
A biosimilar is a biological product that is highly similar to an existing approved reference biological product (also known as the originator or reference product), with no clinically meaningful differences in terms of safety, purity, and potency. Biosimilars are developed to be highly similar to the reference product in terms of structure, function, pharmacokinetics, and clinical efficacy. Alpha Lifetech can provide biosimilar antibody products.
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How can I obtain COA of the reagent that I received?
Please contact us via email info@alphalifetech.com for detailed information about the product.
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Why choose Alpha Lifetech’s product?
Alpha Lifetech's products are chosen for their quality, reliability, and competitive pricing. Our biosimilar antibodies undergo thorough development and testing processes to ensure they meet regulatory requirements and deliver comparable performance to reference products. We prioritize customer satisfaction and strive to provide cost-effective solutions without compromising on quality. -
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How to purify your antibodies?
Protein A/G Chromatography: Protein A and Protein G are affinity chromatography matrices that specifically bind to the Fc region of antibodies, allowing for their purification from complex mixtures.
Ion Exchange Chromatography: Ion exchange chromatography separates proteins based on their net charge at a specific pH.
Size Exclusion Chromatography: Size exclusion chromatography (SEC), also known as gel filtration chromatography, separates proteins based on their size and shape.
Affinity Tag Purification: Some recombinant antibodies are engineered with affinity tags (e.g., His-tag, FLAG-tag) that facilitate purification. Affinity tag purification involves using specific affinity resins or columns that bind to the tag, allowing for purification of the tagged antibodies. Alpha Lifetech has multiple antibody purification strategies. Please contact us via email info@alphalifetech.com for more detailed information.