ADT1070-Basiliximab Biosimilar-Anti-IL2RA/CD25 mAb-Research Grade

Catalog Number

ADT1070

Product Name

ADT1070-Basiliximab Biosimilar-Anti-IL2RA/CD25 mAb-Research Grade

Clonity

Monoclonal

Alternate Names

Alias

CHI621

Host

CHO Cells

Species

Human

Target

IL2RA/CD25

Gene ID

3559

Isotype

IgG1 Kappa

Size

100ug, 1mg, 5mg

Research Area

Immunology

CAS Number

179045-86-4

Chemical Formula

C6378H9844N1698O1997S48

Product Description

Basiliximab (trade name Simulect) is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor of T cells. It is used to prevent rejection in organ transplantation,  especially in kidney transplants.

Mechanism of Action

Basiliximab binds with high-affinity to the alpha-subunit (CD25) of the high-affinity IL-2 receptor. This Inhibitionits IL-2 binding,  which Inhibitionits T-cell activation and prevents the body from mounting an immune response against the foreign kidney.

Metabolism

Most likely removed by opsonization via the reticuloendothelial system when bound to lymphocytes,  or by human antimurine antibody production.

Molecular Weight

143.80 KDa

Application

Elisa,  WB

Purity

>95% as determined by SDS-PAGE

Concentration

batch dependent

Buffer

Supplied in PBS,  PH7.5

Storage

Store at -20 °C for 12 months. Store at -80 °C for long term storage.

Shipping Condition

Shipped on ice packs.

Note

This product is for research use only.

Reactivity

Human,  Cynomolgus,  Rhesus Monkey

Reference