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ADT1076-Befovacimab Biosimilar-(TFPI)-Research Biosimilar Antibody
Antibody

ADT1076-Befovacimab Biosimilar-(TFPI)-Research Biosimilar Antibody

  • Catalog Number ADT1076
  • Host CHO Cells
  • Species Human
  • Target TFPI
  • Application ELISA, WB

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Product Background

This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot.

Product Specification

Catalog Number

ADT1076

Product Name

ADT1076-Befovacimab Biosimilar-(TFPI)-Research Biosimilar Antibody

Clonity

Monoclonal

Alternate Names

anti-TFPI antibody,  anti TFPI antibody,  recombinant TFPI,  TFPI antibody,  anti-TFPI monoclonal antibody,  TFPI antibodies,  TFPI recombinant antibody,  TFPI blocking antibody

Alias

Anti-TFPI,  NN7415,  mab2021

Host

CHO Cells

Species

Human

Target

TFPI

Gene ID

7035

Isotype

IgG4 Kappa

Size

100ug, 1mg, 5mg

Research Area

Immunology

CAS Number

1312299-39-0

Product Description

Concizumab has been used in trials studying the treatment of Haemophilia A and Congenital Bleeding Disorder.

Application

ELISA,  WB

Purity

>95% as determined by SDS-PAGE

Concentration

batch dependent

Buffer

Supplied in PBS,  PH7.5

Storage

Store at -20 °C for 12 months. Store at -80 °C for long term storage.

Shipping Condition

Shipped on ice packs.

Note

This product is for research use only.

Reference

1. Tissue factor pathway inhibitor-alpha inhibits prothrombinase during the initiation of blood coagulation. Wood JP,  et al. Proc Natl Acad Sci U S A,  2013 Oct 29. PMID 24127605,  Free PMC Article
2. The intron 7 -33T>C polymorphism in TFPI gene and cerebral venous thrombosis: evidence for a protective role. Prabhakar P,  et al. Thromb Res,  2012 Oct. PMID 22836130
3. Impaired tissue factor pathway inhibitor function is associated with recurrent venous thromboembolism in patients with first unprovoked deep venous thrombosis. Winckers K,  et al. J Thromb Haemost,  2012 Oct. PMID 22900482