ADT1099-Blinatumomab Biosimilar– Anti-CD19, CD3E mAb – Research Grade
- +1 609-736-0910
- info@alphalifetech.com
- 90 State Street, STE 700 Office 40, Albany, NY 12207 United States
Product Background
Catalog Number |
ADT1099 |
Product Name |
ADT1099-Blinatumomab Biosimilar– Anti-CD19, CD3E mAb – Research Grade |
Alias |
AMG103, BITE MT-103 |
Isotype |
(scFv Kappa-heavy)-(scFv-heavy Kappa) |
Clonity |
Monoclonal |
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Alternate Names anti cd19, mouse cd19, mouse cd19 antibody, anti human cd19, anti-cd19, human cd19, cd19 antibody, anti cd19 antibody, cd19 recombinant antibody, cd19 blocking antibody, CD3E antibody, anti CD3E antibody, CD3E recombinant antibody, CD3E blocking antibody
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Official Symbol |
CD19/CD3E |
Species |
Human |
Expression Host |
CHO Cells |
Reactivity |
Mouse |
Gene ID |
930 |
CAS Number |
853426-35-4 |
Chemical Formula |
C2367H3577N649O772S19 |
Molecular Weight |
54.10 KDa |
Product Description |
Blinatumomab is a bispecific CD19-directed CD3 T-cell engager that binds to CD19 expressed on the surface of cells of B-lineage origin and CD3 expressed on the surface of T cells. It activates endogenous T cells by connecting CD3 in the T-cell receptor complex with CD19 on benign and malignant B cells. Blinatumomab mediates the formation of a synapse between the T cell and the tumor cell, upregulation of cell adhesion molecules, production of cytolytic proteins, release of inflammatory cytokines, and proliferation of T cells, which result in redirected lysis of CD19+ cells. |
Mechanism of Action |
Blinatumomab is a bispecific T-cell engager (BiTE) antibody that targets CD19 on B cells and CD3 on T cells. |
Metabolism |
The metabolic pathway of blinatumomab has not been characterized. Like other protein therapeutics, blinatumomab is expected to be degraded into small peptides and amino acids via catabolic pathways. |
Size |
1mg,5mg |
Research Area |
Cancer |
Application |
Elisa, WB |
Purity |
>95% as determined by SDS-PAGE |
Concentration |
Batch dependent |
Buffer |
Supplied in PBS, PH7.5 |
Storage |
Store at -20 °C for 12 months. Store at -80 °C for long term storage. |
Shipping Condition |
Shipped on ice packs. |
Note |
This product is for research use only. |
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Reference 1. Mikhailova E, et al. Cytometry B Clin Cytom, 2022 Sep. PMID 35796438
2. Shao L, et al. Sci Rep, 2022 Feb 18. PMID 35181722
3. Plaks V, et al. Blood, 2021 Sep 23. PMID 34041526
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FAQ
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What is a biosimilar?
A biosimilar is a biological product that is highly similar to an existing approved reference biological product (also known as the originator or reference product), with no clinically meaningful differences in terms of safety, purity, and potency. Biosimilars are developed to be highly similar to the reference product in terms of structure, function, pharmacokinetics, and clinical efficacy. Alpha Lifetech can provide biosimilar antibody products.
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How can I obtain Request Quote of the reagent that I received?
Please contact us via email info@alphalifetech.com for detailed information about the product.
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Why choose Alpha Lifetech’s product?
Alpha Lifetech's products are chosen for their quality, reliability, and competitive pricing. Our biosimilar antibodies undergo thorough development and testing processes to ensure they meet regulatory requirements and deliver comparable performance to reference products. We prioritize customer satisfaction and strive to provide cost-effective solutions without compromising on quality. -
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How to purify your antibodies?
Protein A/G Chromatography: Protein A and Protein G are affinity chromatography matrices that specifically bind to the Fc region of antibodies, allowing for their purification from complex mixtures.
Ion Exchange Chromatography: Ion exchange chromatography separates proteins based on their net charge at a specific pH.
Size Exclusion Chromatography: Size exclusion chromatography (SEC), also known as gel filtration chromatography, separates proteins based on their size and shape.
Affinity Tag Purification: Some recombinant antibodies are engineered with affinity tags (e.g., His-tag, FLAG-tag) that facilitate purification. Affinity tag purification involves using specific affinity resins or columns that bind to the tag, allowing for purification of the tagged antibodies. Alpha Lifetech has multiple antibody purification strategies. Please contact us via email info@alphalifetech.com for more detailed information.