ADT1106-Brolucizumab Biosimilar-Anti-VEGFA mAb-Research Grade

Catalog Number

ADT1106

Product Name

ADT1106-Brolucizumab Biosimilar-Anti-VEGFA mAb-Research Grade

Clonity

Monoclonal

Alternate Names

anti vegfa antibody,  vegfa antibody,  anti vegfa,  recombinant vegfa,  anti-vegfa antibody,  human vegfa,  anti-mouse vegfa antibody,  anti-vegfa antibody,  anti-vegfa monoclonal antibody,  vegfa antibodies,  vegfa recombinant antibody,  vegfa blocking antibody

Alias

ESBA-1008,  ESBA1008,  RTH258

Host

CHO Cells

Species

Human

Target

VEGFA

Gene ID

7422

Isotype

scFv Kappa-heavy

Size

1mg, 5mg

Research Area

Immunology

CAS Number

1531589-13-5

Product Description

Brolucizumab,  sold under the trade name Beovu,  is a humanized single-chain antibody fragment for the treatment of neovascular (wet) age-related macular degeneration (AMD).

Mechanism of Action

Brolucizumab is a vascular endothelial growth factor (VEGF) Inhibitionitor which targets the major VEGF-A isoforms: VEGF110,  VEGF121,  and VEGF165. Inhibitionition of these VEGF-A isoforms reduce proliferation of endothelial cells,  vascularization of the tissue,  and permeability of the vasculature.

Metabolism

Monoclonal antibodies are expected to undergo proteolysis to smaller peptides and amino acids.

Application

ELISA,  IHC,  IF,  IP,  Flow Cytometry,  Inhibitionition

Purity

>95% as determined by SDS-PAGE

Concentration

batch dependent

Buffer

Supplied in PBS,  PH7.5

Storage

Store at -20 °C for 12 months. Store at -80 °C for long term storage.

Shipping Condition

Shipped on ice packs.

Note

This product is for research use only.

Reference