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ADT1108-Budigalimab Biosimilar-Anti-PDCD1/PD1/CD279 mAb-Research Grade
Antibody

ADT1108-Budigalimab Biosimilar-Anti-PDCD1/PD1/CD279 mAb-Research Grade

  • Catalog Number ADT1108
  • Host CHO Cells
  • Species Human
  • Target PDCD1/PD1/CD279
  • Application Elisa, WB

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Product Background

PD-1 plays a vital role in immune regulation by preventing excessive T cell activation that could lead to tissue damage and autoimmunity. Under normal physiological conditions, PD-1 is upregulated on T cells after activation, serving as a mechanism to limit the duration and intensity of immune responses. This regulatory function is crucial for maintaining self-tolerance and preventing autoimmune diseases.

Product Specification

Catalog Number

ADT1108

Product Name

ADT1108-Budigalimab Biosimilar-Anti-PDCD1/PD1/CD279 mAb-Research Grade

Clonity

Monoclonal

Alternate Names

anti-mouse PDCD1 antibody,  anti-PDCD1 antibody,  anti PDCD1 antibody,  recombinant PDCD1,  PDCD1 antibody,  anti-PDCD1 monoclonal antibody,  PDCD1 antibodies,  PDCD1 recombinant antibody,  PDCD1 blocking antibody,  PD1 recombinant antibody,  PD1 blocking antibody,  CD279 recombinant antibody,  CD279 blocking antibody

Alias

ABBV-181,  PR-1648817

Host

CHO Cells

Species

Human

Target

PDCD1/PD-1/CD279

Gene ID

5133

Isotype

IgG1 Kappa

Size

100ug, 1mg, 5mg

Research Area

Cancer

CAS Number

2098225-93-3

Product Description

Budigalimab is under investigation in clinical trial NCT04807972 (Study to Evaluate Adverse Events and Change in Disease Activity When Intravenous (IV) Infusion of ABBV-927 Is Administered in Combination With IV Modified FOLFIRINOX (Mffx) With or Without IV Budigalimab Compared to Mffx in Adult Participants With Untreated Pancreatic Cancer Metastasis).

Application

Elisa,  WB

Purity

>95% as determined by SDS-PAGE

Concentration

batch dependent

Buffer

Supplied in PBS,  PH7.5

Storage

Store at -20 °C for 12 months. Store at -80 °C for long term storage.

Shipping Condition

Shipped on ice packs.

Note

This product is for research use only.

Reference

1. Ma Y,  et al. Zhonghua Yu Fang Yi Xue Za Zhi,  2023 Jun 6. PMID 37357205
2. Mirsharif ES,  et al. Int Immunopharmacol,  2023 Jun. PMID 37172423
3. Tarique M,  et al. Front Immunol,  2023. PMID 37153623