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ADT1129-Cetrelimab Biosimilar-Anti-PDCD1/PD1/CD279 mAb-Research Grade
Antibody

ADT1129-Cetrelimab Biosimilar-Anti-PDCD1/PD1/CD279 mAb-Research Grade

  • Catalog Number ADT1129
  • Host CHO Cells
  • Species Human
  • Target PDCD1/PD1/CD279
  • Application Elisa, WB

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Product Background

The PD-1 gene, also known as PDCD1 (Programmed Cell Death 1), encodes a protein that plays a crucial role in regulating the immune system. Located on chromosome 2q37.3, PD-1 is primarily expressed on activated T cells, B cells, and some myeloid cells. The PD-1 protein is a member of the CD28 superfamily and functions as an immune checkpoint, which is essential for maintaining immune homeostasis and preventing autoimmunity.

Product Specification

Catalog Number

ADT1129

Product Name

ADT1129-Cetrelimab Biosimilar-Anti-PDCD1/PD1/CD279 mAb-Research Grade

Alias

JNJ-63723283

Clonity

Monoclonal

Alternate Names

anti-mouse pd-1 antibody,  anti-pd-1 antibody,  anti pd-1 antibody,  recombinant pd-1,  pd-1 antibody,  anti-pd-1 monoclonal antibody,  pd-1 antibodies,  pd-1 recombinant antibody,  pd-1 blocking antibody, CD279 recombinant antibody,  CD279 blocking antibody

Host

CHO Cells

Species

Human

Target

PDCD1/PD-1/CD279

Gene ID

5133

Isotype

IgG4 Kappa

Size

1mg, 5mg

Research Area

Cancer

CAS Number

2050478-92-5

Product Description

Cetrelimab is under investigation in clinical trial NCT03547037 (A Study to Evaluate the Safety,  Pharmacokinetics,  Pharmacodynamics,  and Immunogenicity of JNJ-63723283,  an Anti-Programmed Cell Death (PD)-1 Monoclonal Antibody,  as Monotherapy or in Combination With Erdafitinib in Japanese Participants With Advanced Solid Cancers).

Application

Elisa,  WB

Purity

>95% as determined by SDS-PAGE

Concentration

batch dependent

Buffer

Supplied in PBS,  PH7.5

Storage

Store at -20 °C for 12 months. Store at -80 °C for long term storage.

Shipping Condition

Shipped on ice packs.

Note

This product is for research use only.

Reference

1. Cai J,  et al. Immun Inflamm Dis,  2023 May. PMID 37249282
2. Meng FH,  et al. Arterioscler Thromb Vasc Biol,  2023 Jul. PMID 37165876
3. Menichelli D,  et al. Kardiol Pol,  2023. PMID 36929300