Leave Your Message
ADT1140-CMB-401 Biosimilar-Anti-MUC1/CD227 mAb-Research Grade
Antibody

ADT1140-CMB-401 Biosimilar-Anti-MUC1/CD227 mAb-Research Grade

  • Catalog Number ADT1140
  • Host CHO Cells
  • Species Human
  • Target MUC1/CD227
  • Application ELISA, WB

Alpha Lifetech serves a global clientele, offering blocking antibodies to companies and researchers worldwide.

Products Categories
Featured Products
recommended service
quick links
Contact Us

Product Background

MUC1 serves critical roles in lubrication, hydration, and pathogen defense by trapping microbes and particulates, while its cytoplasmic domain modulates cell adhesion and signaling pathways, including those involving ERK and NF-κB.

Product Specification

Catalog Number

ADT1140

Product Name

ADT1140-CMB-401 Biosimilar-Anti-MUC1/CD227 mAb-Research Grade

Clonity

Monoclonal

Alternate Names

anti-mouse cd227 antibody,  anti-cd227 antibody,  anti cd227 antibody,  recombinant cd227,  muc1 antibody,  anti-cd227 monoclonal antibody,  cd227 antibodies,  cd227 recombinant antibody,  cd227 blocking antibody

Alias

hPAM4,  hPAM4 IgG-DOTA,  hPAM4-DOTA

Host

CHO Cells

Species

Human

Target

MUC1/CD227

Gene ID

4582

Isotype

IgG1 Kappa

Size

100ug, 1mg, 5mg

Research Area

Cancer

CAS Number

1462876-11-4

Product Description

Yttrium (90Y) clivatuzumab tetraxetan (trade name hPAM4-Cide) is a humanized monoclonal antibody-drug conjugate designed for the treatment of pancreatic cancer. The antibody part,  clivatuzumab (targeted at MUC1),  is conjugated with tetraxetan,  a chelator for yttrium-90,  a radioisotope which destroys the tumour cells.

Application

ELISA,  WB

Purity

>95% as determined by SDS-PAGE

Concentration

batch dependent

Buffer

Supplied in PBS,  PH7.5

Storage

Store at -20 °C for 12 months. Store at -80 °C for long term storage.

Shipping Condition

Shipped on ice packs.

Note

This product is for research use only.

Reference

1. Azekawa S,  et al. BMJ Open Respir Res,  2023 May. PMID 37230764
2. de Haan A,  et al. Kidney Int,  2023 May. PMID 37085259
3. Lucarelli G,  et al. Int J Mol Sci,  2023 Mar 2. PMID 36902242