ADT1145-Conatumumab Biosimilar-Anti-TNFRSF10B/CD262 mAb-Research Grade
- +1 609-736-0910
- info@alphalifetech.com
- 90 State Street, STE 700 Office 40, Albany, NY 12207 United States
Product Background
Catalog Number |
ADT1145 |
Product Name |
ADT1145-Conatumumab Biosimilar-Anti-TNFRSF10B/CD262 mAb-Research Grade |
Clonity |
Monoclonal |
|
Alternate Names TNFRSF10B antibody, CD262 antibody, cd262 mouse, anti-mouse CD262 antibody, anti-CD262 antibody, anti CD262 antibody, recombinant CD262, anti-CD262 monoclonal antibody, CD262 antibodies, CD262 recombinant antibody, CD262 blocking antibody, TNFRSF10B recombinant antibody, TNFRSF10B blocking antibody |
|
Alias |
AMG 655, TRAIL-R2mAb, XG1-048vw
|
Host |
CHO Cells |
Species |
Human |
Target |
TNFRSF10B/CD262 |
Gene ID |
8795 |
Isotype |
IgG1 Kappa |
Size |
100ug, 1mg, 5mg |
Research Area |
Cancer |
CAS Number |
896731-82-1 |
Product Description |
Conatumumab (originally AMG-655) is a monoclonal antibody developed for the treatment of cancer. It is a fully human monoclonal agonist antibody directed against the extracellular domain of human TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) receptor 2 (TR-2, death receptor 5) with potential antineoplastic activity. |
Mechanism of Action |
Conatumumab is a monoclonal antibody targeting death receptor 5 (DR5), which is involved in inducing apoptosis in cancer cells.
Apoptosis Induction: By binding to DR5, Conatumumab can tri
|
Metabolism |
Conatumumab has a long half-life, consistent with other monoclonal antibodies. |
Application |
ELISA, WB |
Purity |
>95% as determined by SDS-PAGE |
Concentration |
batch dependent |
Buffer |
Supplied in PBS, PH7.5 |
Storage |
Store at -20 °C for 12 months. Store at -80 °C for long term storage. |
Shipping Condition |
Shipped on ice packs. |
Note |
This product is for research use only. |
Reactivity |
Human |
Reference |
1. Mora-Molina R, et al. Int J Mol Sci, 2022 Aug 12. PMID 36012252
2. Qin J, et al. Expert Rev Respir Med, 2022 Jul. PMID 35822538
3. Sullivan GP, et al. Dev Cell, 2020 Mar 23. PMID 32109381
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