ADT1181-Dostarlimab Biosimilar-Anti-PDCD1/PD1/CD279 mAb-Research Grade

Catalog Number

ADT1181

Product Name

ADT1181-Dostarlimab Biosimilar-Anti-PDCD1/PD1/CD279 mAb-Research Grade

Alias

ANB-011,  TSR-042

Clonity

Monoclonal

Alternate Names

anti-mouse pd-1 antibody,  anti-pd-1 antibody,  anti pd-1 antibody,  recombinant pd-1,  pd-1 antibody,  anti-pd-1 monoclonal antibody,  pd-1 antibodies,  pd-1 recombinant antibody,  pd-1 blocking antibody, CD279 recombinant antibody,  CD279 blocking antibody

Host

CHO Cells

Species

Human

Target

PDCD1/PD-1/CD279

Gene ID

5133

Isotype

IgG4 Kappa

Size

100ug, 1mg, 5mg

Research Area

Cancer

CAS Number

2022215-59-2

Chemical Formula

C6420H9832N1680O2014S44

Product Description

Dostarlimab,  sold under the brand name Jemperli,  is a monoclonal antibody medication used for the treatment of endometrial cancer.

Mechanism of Action

Approximately 13-30% of recurrent endometrial cancers involve microsatellite instability (MSI) or mismatch repair deficiency (dMMR). The mutations resulting in dMMR endometrial cancers are primarily somatic in nature (~90%),  although 5-10% of cases involve germline mutations. Cancers that have mutations resulting in dMMR can upregulate the expression of programmed death receptor-1 (PD-1) ligands 1 and 2 (PD-L1 and -L2) - PD-1 is found on T-cells and,  when activated,  Inhibitionits their proliferation and the production of cytokines. The binding of these ligands to PD-1 thereby functions as an immune checkpoint that downregulates the anti-tumor immune response.

Metabolism

The metabolism of dostarlimab has not been characterized,  but it is expected to be degraded via catabolic pathways into smaller peptides and amino acids.

Application

ELISA, WB

Purity

>95% as determined by SDS-PAGE

Concentration

batch dependent

Buffer

Supplied in PBS,  PH7.5

Storage

Store at -20 °C for 12 months. Store at -80 °C for long term storage.

Shipping Condition

Shipped on ice packs.

Note

This product is for research use only.

Reference