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Product Background
Catalog Number |
ADT1224 |
Product Name |
ADT1224-Etanercept Biosimilar-(TNF Receptor)-Research Biosimilar Antibody |
Clonity |
Monoclonal |
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Alternate Names anti-mouse TNF Receptor antibody, anti-TNF Receptor antibody, anti TNF Receptor antibody, recombinant TNF Receptor, TNF Receptor antibody, anti-TNF Receptor monoclonal antibody, TNF Receptor antibodies, TNF Receptor recombinant antibody, TNF Receptor blocking antibody |
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Alias |
etanercept-szzs, etanercept-ykro, Recombinant human TNF, rhu TNFR:Fc, rhu-TNFR:Fc, TNFR-Immunoadhesin
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Host |
CHO Cells |
Species |
Human |
Target |
TNF Receptor |
Size |
1mg, 5mg |
Research Area |
Immunology |
CAS Number |
185243-69-0 |
Chemical Formula |
C2224H3475N621O698S36 |
Product Description |
Etanercept interfering with tumor necrosis factor (TNF), a soluble inflammatory cytokine, by acting as a TNF Inhibitionitor. |
Mechanism of Action |
There are two distinct receptors for TNF (TNFRs), a 55 kilodalton protein (p55) and a 75 kilodalton protein (p75). The biological activity of TNF is dependent upon binding to either cell surface receptor (p75 or p55). Etanercept is a dimeric soluble form of the p75 TNF receptor that can bind to two TNF molecules, thereby effectively removing them from circulation. Notably, etancerpt is only capable of binding to the active trimeric form of TNF as its binding site is located in the cleft between subunits.TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Increased levels of TNF are found in tissues and fluids of those with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis. |
Metabolism |
As etanercept is a fusion protein antibody, it is assumed to be metabolized via proteinases similarly to endogenous proteins. |
Molecular Weight |
51.23 KDa (Monomer) |
Application |
ELISA, WB |
Purity |
>95% as determined by SDS-PAGE |
Concentration |
batch dependent |
Buffer |
Supplied in PBS, PH7.5 |
Storage |
Store at -20 °C for 12 months. Store at -80 °C for long term storage. |
Shipping Condition |
Shipped on ice packs. |
Note |
This product is for research use only. |
Reference |
1. Balkwill, F. (2006). “TNF-alpha in promotion and progression of cancer.” Cancer and Metastasis Reviews, 25(3), 409-416. DOI: 10.1007/s10555-006-9008-5.
2. Peters, A. M., et al. (2015). “The role of TNF receptors in the regulation of immune responses.” Nature Reviews Immunology, 15(1), 1-10. DOI: 10.1038/nri.2014.139.
3. Ashkenazi, A., & Dixit, V. M. (1998). “Death receptors: Signaling and modulation.” Science, 281(5381), 1305-1308. DOI: 10.1126/science.281.5381.1305.
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