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Product Background
Catalog Number |
ADT1234 |
Product Name |
ADT1234-Fabrazyme Biosimilar-(GLA)-Research Biosimilar Antibody |
Alternate Names |
anti-mouse GLA antibody, anti-GLA antibody, anti GLA antibody, recombinant GLA, GLA antibody, anti-GLA monoclonal antibody, GLA antibodies, GLA recombinant antibody, GLA blocking antibody |
Alias |
agalsidase beta |
Clonity |
Monoclonal |
Host |
CHO Cells |
Species |
Human |
Target |
GLA |
Size |
1mg, 5mg |
Research Area |
Immunology |
Chemical Formula |
C2029H3080N544O587S27 |
Product Description |
Alpha-galactosidase is a glycoside hydrolase enzyme that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. Glycosidase is an important class of enzyme catalyzing many catabolic processes, including cleaving glycoproteins and glycolipids, and polysaccharides. Specifically, α-GAL catalyzes the removal of the terminal α-galactose from oligosaccharides. |
Mechanism of Action |
α-galactosidase A is uptaken by cells via the mannose 6 phosphate receptor. Agalsidase beta hydrolyzes globotriaosylceramide and other glycosphingolipids that would normally be hydrolyzed by endogenous α-galactosidase A. Preventing the accumulation of glycosphingolipids prevents or reduces the severity of manifestations of Fabry disease such as renal failure, cardiomyopathy, or cerebrovascular events. |
Metabolism |
Data regarding the metabolism of agalsidase beta is not readily available. However, protein drugs are expected to be degraded by proteases and other catalytic enzymes to smaller peptides and amino acids. |
Molecular Weight |
55KDa |
Application |
ELISA, WB |
Purity |
>95% as determined by SDS-PAGE |
Concentration |
batch dependent |
Buffer |
Supplied in PBS, PH7.5 |
Storage |
Store at -20 °C for 12 months. Store at -80 °C for long term storage. |
Shipping Condition |
Shipped on ice packs. |
Note |
This product is for research use only. |