ADT1265-Gantenerumab Biosimilar-Anti-APP, Abeta42, Abeta40 mAb-Research Grade
- +1 609-736-0910
- info@alphalifetech.com
- 90 State Street, STE 700 Office 40, Albany, NY 12207 United States
Product Background
Catalog Number |
ADT1265 |
Product Name |
ADT1265-Gantenerumab Biosimilar-Anti-APP, Abeta42, Abeta40 mAb-Research Grade |
Alias |
R1450 |
Isotype |
IgG1 Kappa |
Clonity |
Monoclonal |
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Alternate Names APP antibody, human APP antibody, recombinant APP, anti-APP, anti-APP antibody, anti-APP monoclonal antibody, anti APP antibody, APP recombinant antibody, APP blocking antibody |
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Official Symbol |
APP/Abeta40/Abeta42 |
Species |
Human |
Expression Host |
CHO Cells |
Reactivity |
Human |
Gene ID |
351 |
CAS Number |
1043556-46-2 |
Product Description |
Gantenerumab is a monoclonal antibody for the treatment of Alzheimer's disease being developed by Hoffmann-La Roche pharmaceuticals. Gantenerumab binds to and clears aggregated beta amyloid fibers. |
Mechanism of Action |
Gantenerumab is a monoclonal antibody targeting amyloid-beta (Aβ) plaques, which are associated with Alzheimer’s disease. |
Metabolism |
Gantenerumab has a long half-life, consistent with other monoclonal antibodies. Its pharmacokinetics involve distribution into the bloodstream and brain tissues. |
Size |
100ug,1mg,5mg |
Research Area |
Neurobiology |
Application |
Elisa, WB |
Purity |
>95% as determined by SDS-PAGE |
Concentration |
Batch dependent |
Buffer |
Supplied in PBS, PH7.5 |
Storage |
Store at -20 °C for 12 months. Store at -80 °C for long term storage. |
Shipping Condition |
Shipped on ice packs. |
Note |
This product is for research use only. |
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Reference 1. Poore AT, et al. Inorg Chem, 2023 Jul 10. PMID 37369063
2. Noguchi-Shinohara M, et al. Parkinsonism Relat Disord, 2023 Jun. PMID 37201326
3. Firouzi R, et al. Int J Mol Sci, 2023 May 3. PMID 37175868
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FAQ
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What is a biosimilar?
A biosimilar is a biological product that is highly similar to an existing approved reference biological product (also known as the originator or reference product), with no clinically meaningful differences in terms of safety, purity, and potency. Biosimilars are developed to be highly similar to the reference product in terms of structure, function, pharmacokinetics, and clinical efficacy. Alpha Lifetech can provide biosimilar antibody products.
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How can I obtain Request Quote of the reagent that I received?
Please contact us via email info@alphalifetech.com for detailed information about the product.
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Why choose Alpha Lifetech’s product?
Alpha Lifetech's products are chosen for their quality, reliability, and competitive pricing. Our biosimilar antibodies undergo thorough development and testing processes to ensure they meet regulatory requirements and deliver comparable performance to reference products. We prioritize customer satisfaction and strive to provide cost-effective solutions without compromising on quality. -
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How to purify your antibodies?
Protein A/G Chromatography: Protein A and Protein G are affinity chromatography matrices that specifically bind to the Fc region of antibodies, allowing for their purification from complex mixtures.
Ion Exchange Chromatography: Ion exchange chromatography separates proteins based on their net charge at a specific pH.
Size Exclusion Chromatography: Size exclusion chromatography (SEC), also known as gel filtration chromatography, separates proteins based on their size and shape.
Affinity Tag Purification: Some recombinant antibodies are engineered with affinity tags (e.g., His-tag, FLAG-tag) that facilitate purification. Affinity tag purification involves using specific affinity resins or columns that bind to the tag, allowing for purification of the tagged antibodies. Alpha Lifetech has multiple antibody purification strategies. Please contact us via email info@alphalifetech.com for more detailed information.