ADT1279-Girentuximab Biosimilar-Anti-CA9 mAb-Research Grade
- +1 609-736-0910
- info@alphalifetech.com
- 90 State Street, STE 700 Office 40, Albany, NY 12207 United States
Product Background
Catalog Number |
ADT1279 |
Product Name |
ADT1279-Girentuximab Biosimilar-Anti-CA9 mAb-Research Grade |
Alias |
WX-G250, cG250 |
Isotype |
IgG1 Kappa |
Clonity |
Monoclonal |
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Alternate Names recombinant CA9 antibody, anti CA9 antibody, CA IX antibody, anti carbonic anhydrase 9 antibody, anti human CA9 recombinant antibody, CA9 antibody, human CA9 antibody, mouse CA9, human CA9, recombinant CA9, anti-CA9, anti-CA9 antibody, anti-CA9 monoclonal antibody, CA9 recombinant antibody, CA9 blocking antibody |
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Official Symbol |
CA9 |
Species |
Human |
Expression Host |
CHO Cells |
Reactivity |
Human |
Gene ID |
768 |
CAS Number |
916138-87-9 |
Product Description |
Girentuximab (trade name Rencarex) is a chimeric IgG1 monoclonal antibody to carbonic anhydrase IX (CAIX). CAIX is expressed on the surface of most renal cancer cells and is hypothesized to be on the surface of other tumor cells. It is investigational agent in clinical trials for renal cell carcinoma. Its development was suspended as a "naked" or unconjugated antibody during phase III trials due to efficacy. |
Mechanism of Action |
Mechanism of action of girentuximab is antibody dependent cellular cytotoxicity (ADCC). As a monotherapy in metastatic renal cell carcinomas(RCC), girentuximab demonstrated minimal clinical activity with a 3% partial response rate and a median survival of 16 months. In vitro data suggest that the number of activated ADCC effector cells can be upregulated by low dose interleukin 2 (IL2) administered in a pulsatile fashion. |
Metabolism |
Girentuximab has a moderate to long half-life. |
Size |
100ug,1mg,5mg |
Research Area |
Cancer |
Application |
WB, Functional assay, IF, Neut, ELISA, FC, IP, PK, IHC, Activ |
Purity |
>95% as determined by SDS-PAGE |
Concentration |
Batch dependent |
Buffer |
Supplied in PBS, PH7.5 |
Storage |
Store at -20 °C for 12 months. Store at -80 °C for long term storage. |
Shipping Condition |
Shipped on ice packs. |
Note |
This product is for research use only. |
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Reference 1. Shamis SAK, et al. Diagn Pathol, 2023 Apr 15. PMID 37061698
2. Venturella M, et al. Int J Mol Sci, 2023 Mar 24. PMID 37047096
3. Rezuchova I, et al. Int J Mol Sci, 2023 Feb 21. PMID 36901756
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FAQ
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What is a biosimilar?
A biosimilar is a biological product that is highly similar to an existing approved reference biological product (also known as the originator or reference product), with no clinically meaningful differences in terms of safety, purity, and potency. Biosimilars are developed to be highly similar to the reference product in terms of structure, function, pharmacokinetics, and clinical efficacy. Alpha Lifetech can provide biosimilar antibody products.
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How can I obtain Request Quote of the reagent that I received?
Please contact us via email info@alphalifetech.com for detailed information about the product.
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Why choose Alpha Lifetech’s product?
Alpha Lifetech's products are chosen for their quality, reliability, and competitive pricing. Our biosimilar antibodies undergo thorough development and testing processes to ensure they meet regulatory requirements and deliver comparable performance to reference products. We prioritize customer satisfaction and strive to provide cost-effective solutions without compromising on quality. -
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How to purify your antibodies?
Protein A/G Chromatography: Protein A and Protein G are affinity chromatography matrices that specifically bind to the Fc region of antibodies, allowing for their purification from complex mixtures.
Ion Exchange Chromatography: Ion exchange chromatography separates proteins based on their net charge at a specific pH.
Size Exclusion Chromatography: Size exclusion chromatography (SEC), also known as gel filtration chromatography, separates proteins based on their size and shape.
Affinity Tag Purification: Some recombinant antibodies are engineered with affinity tags (e.g., His-tag, FLAG-tag) that facilitate purification. Affinity tag purification involves using specific affinity resins or columns that bind to the tag, allowing for purification of the tagged antibodies. Alpha Lifetech has multiple antibody purification strategies. Please contact us via email info@alphalifetech.com for more detailed information.