ADT1357-Lexatumumab Biosimilar-Anti-TNFRSF10B/CD262 mAb-Research Grade
- +1 609-736-0910
- info@alphalifetech.com
- 90 State Street, STE 700 Office 40, Albany, NY 12207 United States
Product Background
Catalog Number |
ADT1357 |
Product Name |
ADT1357-Lexatumumab Biosimilar-Anti-TNFRSF10B/CD262 mAb-Research Grade |
Clonity |
Monoclonal |
|
Alternate Names TNFRSF10B antibody, CD262 antibody, cd262 mouse, anti-mouse CD262 antibody, anti-CD262 antibody, anti CD262 antibody, recombinant CD262, anti-CD262 monoclonal antibody, CD262 antibodies, CD262 recombinant antibody, CD262 blocking antibody, TNFRSF10B recombinant antibody, TNFRSF10B blocking antibody |
|
Alias |
HGS-ETR2
|
Host |
CHO Cells |
Species |
Human |
Target |
TNFRSF10B/CD262 |
Gene ID |
8795 |
Isotype |
IgG1 Lambda |
Size |
1mg, 5mg |
Research Area |
Cancer |
CAS Number |
845816-02-6 |
Product Description |
Lexatumumab (also known as ETR2-ST01) is an experimental agonistic human monoclonal antibody against TRAIL-R2 (DR5, APO-2), intended for the treatment of cancer. HGS-ETR2 antibodies were generated by Human Genome Sciences through a collaboration with Cambridge Antibody Technology. Development was discontinued in 2015. |
Mechanism of Action |
Lexatumumab agonizes the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor 2 (TRAIL-R2), triggering the extrinsic apoptotic pathway.
|
Metabolism |
Lexatumumab has a long half-life and is distributed throughout the bloodstream and tissues. |
Application |
ELISA, IP, FC, Functional assay, Neut, IF |
Purity |
>95% as determined by SDS-PAGE |
Concentration |
batch dependent |
Buffer |
Supplied in PBS, PH7.5 |
Storage |
Store at -20 °C for 12 months. Store at -80 °C for long term storage. |
Shipping Condition |
Shipped on ice packs. |
Note |
This product is for research use only. |
Reactivity |
Human |
Reference |
1. Mora-Molina R, et al. Int J Mol Sci, 2022 Aug 12. PMID 36012252
2. Qin J, et al. Expert Rev Respir Med, 2022 Jul. PMID 35822538
3. Sullivan GP, et al. Dev Cell, 2020 Mar 23. PMID 32109381
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