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Product Background
Catalog Number |
ADT1381 |
Product Name |
ADT1381-Magrolimab Biosimilar-Anti-CD47 mAb-Research Grade |
Alias |
Hu5F9-G4 |
Isotype |
IgG4 Kappa |
Clonity |
Monoclonal |
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Alternate Names CD47 antibody, mouse CD47, human CD47, anti CD47, anti-CD47 antibody, human CD47 antibody, recombinant CD47, anti-CD47, anti-CD47 monoclonal antibody, anti CD47 antibody, CD47 recombinant antibody, CD47 blocking antibody |
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Official Symbol |
CD47 |
Species |
Human |
Expression Host |
CHO Cells |
Reactivity |
Human |
CAS Number |
2169232-81-7 |
Product Description |
Magrolimab is under investigation in clinical trial NCT02953782 (Trial of Magrolimab (Hu5f9-g4) in Combination With Cetuximab in Participants With Solid Tumors and Advanced Colorectal Cancer). |
Mechanism of Action |
Magrolimab is a monoclonal antibody that targets CD47, a "don't eat me" signal on cancer cells. |
Metabolism |
Lebrikizumab has a long half-life and is distributed throughout the bloodstream and tissues. |
Gene ID |
961 |
Size |
100ug,1mg,5mg |
Research Area |
Cancer |
Application |
Elisa, WB |
Purity |
>95% as determined by SDS-PAGE |
Concentration |
Batch dependent |
Buffer |
Supplied in PBS, PH7.5 |
Storage |
Store at -20 °C for 12 months. Store at -80 °C for long term storage. |
Shipping Condition |
Shipped on ice packs. |
Note |
This product is for research use only. |
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Reference 1. Jie XL, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2023 May. PMID 37248568
2. Beckett AN, et al. J Immunother Cancer, 2023 Mar. PMID 36918226
3. Abd El-Fattah EE, et al. Int Immunopharmacol, 2022 Dec. PMID 36435064
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FAQ
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What is a biosimilar?
A biosimilar is a biological product that is highly similar to an existing approved reference biological product (also known as the originator or reference product), with no clinically meaningful differences in terms of safety, purity, and potency. Biosimilars are developed to be highly similar to the reference product in terms of structure, function, pharmacokinetics, and clinical efficacy. Alpha Lifetech can provide biosimilar antibody products.
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How can I obtain COA of the reagent that I received?
Please contact us via email info@alphalifetech.com for detailed information about the product.
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Why choose Alpha Lifetech’s product?
Alpha Lifetech's products are chosen for their quality, reliability, and competitive pricing. Our biosimilar antibodies undergo thorough development and testing processes to ensure they meet regulatory requirements and deliver comparable performance to reference products. We prioritize customer satisfaction and strive to provide cost-effective solutions without compromising on quality. -
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How to purify your antibodies?
Protein A/G Chromatography: Protein A and Protein G are affinity chromatography matrices that specifically bind to the Fc region of antibodies, allowing for their purification from complex mixtures.
Ion Exchange Chromatography: Ion exchange chromatography separates proteins based on their net charge at a specific pH.
Size Exclusion Chromatography: Size exclusion chromatography (SEC), also known as gel filtration chromatography, separates proteins based on their size and shape.
Affinity Tag Purification: Some recombinant antibodies are engineered with affinity tags (e.g., His-tag, FLAG-tag) that facilitate purification. Affinity tag purification involves using specific affinity resins or columns that bind to the tag, allowing for purification of the tagged antibodies. Alpha Lifetech has multiple antibody purification strategies. Please contact us via email info@alphalifetech.com for more detailed information.