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Product Background
Catalog Number |
ADT1436 |
Product Name |
ADT1436-Nesvacumab Biosimilar-Anti-ANGPT2 mAb-Research Grade |
Alias |
REGN-910 |
Isotype |
IgG1 |
Clonity |
Monoclonal |
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Alternate Names ANGPT2 antibody, Anti-ANGPT2, Anti-ANGPT2 therapeutic antibody, anti ANGPT2, anti-ANGPT2 antibody, human ANGPT2 antibody, recombinant ANGPT2, ANGPT2 recombinant antibody, ANGPT2 blocking antibody |
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Official Symbol |
ANGPT2 |
Species |
Human |
Expression Host |
CHO Cells |
Reactivity |
Human |
CAS Number |
1296818-77-3 |
Product Description |
Nesvacumab is an experimental monoclonal antibody originally designed for the treatment of cancer. It targets the protein angiopoietin 2. |
Mechanism of Action |
Nesvacumab is a monoclonal antibody targeting angiopoietin-2 (Ang-2), a protein involved in angiogenesis. |
Metabolism |
Nesvacumab has a long half-life and is distributed throughout the bloodstream and tissues. |
Gene ID |
285 |
Size |
1mg,5mg |
Research Area |
Cancer |
Application |
Elisa, WB |
Purity |
>95% as determined by SDS-PAGE |
Concentration |
Batch dependent |
Buffer |
Supplied in PBS, PH7.5 |
Storage |
Store at -20 °C for 12 months. Store at -80 °C for long term storage. |
Shipping Condition |
Shipped on ice packs. |
Note |
This product is for research use only. |
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Reference 1. Wang B, et al. Genet Test Mol Biomarkers, 2023 Jun. PMID 37382908
2. Kawagishi N, et al. Viruses, 2023 Jan 7. PMID 36680221
3. Yang S, et al. Front Immunol, 2022. PMID 36172371
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FAQ
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What is a biosimilar?
A biosimilar is a biological product that is highly similar to an existing approved reference biological product (also known as the originator or reference product), with no clinically meaningful differences in terms of safety, purity, and potency. Biosimilars are developed to be highly similar to the reference product in terms of structure, function, pharmacokinetics, and clinical efficacy. Alpha Lifetech can provide biosimilar antibody products.
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How can I obtain COA of the reagent that I received?
Please contact us via email info@alphalifetech.com for detailed information about the product.
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Why choose Alpha Lifetech’s product?
Alpha Lifetech's products are chosen for their quality, reliability, and competitive pricing. Our biosimilar antibodies undergo thorough development and testing processes to ensure they meet regulatory requirements and deliver comparable performance to reference products. We prioritize customer satisfaction and strive to provide cost-effective solutions without compromising on quality. -
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How to purify your antibodies?
Protein A/G Chromatography: Protein A and Protein G are affinity chromatography matrices that specifically bind to the Fc region of antibodies, allowing for their purification from complex mixtures.
Ion Exchange Chromatography: Ion exchange chromatography separates proteins based on their net charge at a specific pH.
Size Exclusion Chromatography: Size exclusion chromatography (SEC), also known as gel filtration chromatography, separates proteins based on their size and shape.
Affinity Tag Purification: Some recombinant antibodies are engineered with affinity tags (e.g., His-tag, FLAG-tag) that facilitate purification. Affinity tag purification involves using specific affinity resins or columns that bind to the tag, allowing for purification of the tagged antibodies. Alpha Lifetech has multiple antibody purification strategies. Please contact us via email info@alphalifetech.com for more detailed information.