ADT1443-Nivolumab Biosimilar-Anti-PDCD1/PD1/CD279 mAb-Research Grade
- +1 609-736-0910
- info@alphalifetech.com
- 90 State Street, STE 700 Office 40, Albany, NY 12207 United States
Product Background
Catalog Number |
ADT1443 |
Product Name |
ADT1443-Nivolumab Biosimilar-Anti-PDCD1/PD1/CD279 mAb-Research Grade |
Alias |
BMS-936558, MDX-1106 |
Isotype |
IgG4 Kappa |
Clonity |
Monoclonal |
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Alternate Names anti-mouse pd-1 antibody, anti-pd-1 antibody, anti pd-1 therapy, anti pd-1 antibody, recombinant pd-1, pd-1 antibody, anti-pd-1 monoclonal antibody, CD279 antibody, anti CD279, anti-CD279 antibody, human CD279 antibody, recombinant CD279, CD279 recombinant antibody, CD279 blocking antibody |
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Official Symbol |
PDCD1/PD-1/CD279 |
Species |
Human |
Expression Host |
CHO Cells |
Reactivity |
Human |
CAS Number |
946414-94-4 |
Chemical Formula |
C6362H9862N1712O1995S42 |
Molecular Weight |
143.60 KDa |
Product Description |
The ligands PD-L1 and PD-L2 bind to the PD-1 receptor on T-cells, Inhibitioniting the action of these cells. Tumor cells express PD-L1 and PD-L2. Nivolumab binds to PD-1, preventing PD-L1 and PD-L2 from Inhibitioniting the action of T-cells, restoring a patient's tumor-specific T-cell response. |
Mechanism of Action |
Nivolumab is a monoclonal antibody that targets the programmed cell death-1 (PD-1) receptor on T-cells. |
Metabolism |
There have not been formal studies regarding the specific metabolism of nivolumab but as a human monoclonal antibody, it has been suggested to be degraded to small peptides and individual amino acids. |
Gene ID |
5133 |
Size |
1mg,5mg |
Research Area |
Cancer |
Application |
IF, IP, Neut, Functional assay, ELISA, FC, ICC |
Purity |
>95% as determined by SDS-PAGE |
Concentration |
Batch dependent |
Buffer |
Supplied in PBS, PH7.5 |
Storage |
Store at -20 °C for 12 months. Store at -80 °C for long term storage. |
Shipping Condition |
Shipped on ice packs. |
Note |
This product is for research use only. |
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Reference 1. Ma Y, et al. Zhonghua Yu Fang Yi Xue Za Zhi, 2023 Jun 6. PMID 37357205
2. Mirsharif ES, et al. Int Immunopharmacol, 2023 Jun. PMID 37172423
3. Tarique M, et al. Front Immunol, 2023. PMID 37153623
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FAQ
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What is a biosimilar?
A biosimilar is a biological product that is highly similar to an existing approved reference biological product (also known as the originator or reference product), with no clinically meaningful differences in terms of safety, purity, and potency. Biosimilars are developed to be highly similar to the reference product in terms of structure, function, pharmacokinetics, and clinical efficacy. Alpha Lifetech can provide biosimilar antibody products.
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How can I obtain Request Quote of the reagent that I received?
Please contact us via email info@alphalifetech.com for detailed information about the product.
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Why choose Alpha Lifetech’s product?
Alpha Lifetech's products are chosen for their quality, reliability, and competitive pricing. Our biosimilar antibodies undergo thorough development and testing processes to ensure they meet regulatory requirements and deliver comparable performance to reference products. We prioritize customer satisfaction and strive to provide cost-effective solutions without compromising on quality. -
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How to purify your antibodies?
Protein A/G Chromatography: Protein A and Protein G are affinity chromatography matrices that specifically bind to the Fc region of antibodies, allowing for their purification from complex mixtures.
Ion Exchange Chromatography: Ion exchange chromatography separates proteins based on their net charge at a specific pH.
Size Exclusion Chromatography: Size exclusion chromatography (SEC), also known as gel filtration chromatography, separates proteins based on their size and shape.
Affinity Tag Purification: Some recombinant antibodies are engineered with affinity tags (e.g., His-tag, FLAG-tag) that facilitate purification. Affinity tag purification involves using specific affinity resins or columns that bind to the tag, allowing for purification of the tagged antibodies. Alpha Lifetech has multiple antibody purification strategies. Please contact us via email info@alphalifetech.com for more detailed information.