ADT1457-Olaratumab Biosimilar-(PDGFRA/PDGFR2/CD140a)-Research Biosimilar Antibody
- +1 609-736-0910
- info@alphalifetech.com
- 90 State Street, STE 700 Office 40, Albany, NY 12207 United States
Product Background
Catalog Number |
ADT1457 |
Product Name |
ADT1457-Olaratumab Biosimilar-(PDGFRA/PDGFR2/CD140a)-Research Biosimilar Antibody |
Alias |
3G3, IMC-3G3, LY3012207 |
Clonity |
Monoclonal |
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Alternate Names anti-mouse PDGFRA antibody, anti-PDGFRA antibody, anti PDGFRA antibody, recombinant PDGFRA, PDGFRA antibody, anti-PDGFRA monoclonal antibody, PDGFRA antibodies, PDGFRA recombinant antibody, PDGFRA blocking antibody, PDGFR2 recombinant antibody, PDGFR2 blocking antibody, CD140a recombinant antibody, CD140a blocking antibody, |
|
Host |
CHO Cells |
Species |
Human |
Target |
PDGFRA/PDGFR2/CD140a |
Isotype |
IgG1 Kappa |
Size |
1mg, 5mg |
Research Area |
Cancer |
CAS Number |
1024603-93-7 |
Chemical Formula |
C6554H10076N1736O2048S40 |
Product Description |
Olaratumab, sold under the brand name Lartruvo, is a monoclonal antibody medication developed by Eli Lilly and Company for the treatment of solid tumors. It is directed against the platelet-derived growth factor receptor alpha. It was removed from the United States and European Union markets in 2019, due to insufficient proof of its medical advantage (see below "Medical uses"). |
Mechanism of Action |
Olaratumab blocks ligand-induced tumor cell proliferation, and Inhibitionits receptor autophosphorylation and ligand-induced phosphorylation of the downstream signaling molecules protein kinase B (Akt) and mitogen-activated protein kinase. PDGFR signalling is a type of tyrosine kinase-mediated pathway that normally regulates cell growth, chemotaxis, and mesenchymal stem cell differentiation. It also promotes internalization of PDGFR thus alters the surface levels of PDGFR. |
Metabolism |
Mainly degraded nonspecifically by proteolytic enzymes. |
Molecular Weight |
147.20 KDa |
Application |
IF, IP, Neut, Functional assay, ELISA, FC |
Purity |
>95% as determined by SDS-PAGE |
Concentration |
batch dependent |
Buffer |
Supplied in PBS, PH7.5 |
Storage |
Store at -20 °C for 12 months. Store at -80 °C for long term storage. |
Shipping Condition |
Shipped on ice packs. |
Note |
This product is for research use only. |
Reference |
1. Heinrich et al. (2003) identified PDGFRA mutations in GIST (Science).
2. WHO Classification of Tumours (2020) outlines molecular subtypes of GIST.
3. FDA approval of avapritinib (2020) for PDGFRA exon 18-mutant GIST.
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