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ADT1483-Ozanezumab Biosimilar-(RTN4/NOGO)-Research Biosimilar Antibody
Antibody

ADT1483-Ozanezumab Biosimilar-(RTN4/NOGO)-Research Biosimilar Antibody

  • Catalog Number ADT1483
  • Host CHO Cells
  • Species Mouse
  • Target GPNMB extracellular domain
  • Application IP, IF, Functional assay, FC, Neut, ELISA, ICC

By maintaining stringent quality control throughout the production process, we provide blocking antibody that meet the highest standards of purity and performance, making them ideal for research applications.

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Product Background

RTN4, commonly known as Nogo, is a member of the reticulon family of proteins, which are integral to shaping the endoplasmic reticulum (ER) membrane. The RTN4 gene produces three major isoforms via alternative splicing: Nogo-A (the largest and most studied), Nogo-B, and Nogo-C.

Product Specification

Catalog Number

ADT1483

Product Name

ADT1483-Ozanezumab Biosimilar-(RTN4/NOGO)-Research Biosimilar Antibody

Clonity

Monoclonal

Alternate Names

anti-mouse RTN4 antibody,  anti-RTN4 antibody,  anti RTN4 antibody,  recombinant RTN4,  RTN4 antibody,  anti-RTN4 monoclonal antibody,  RTN4 antibodies,  RTN4 recombinant antibody,  RTN4 blocking antibody,  NOGO recombinant antibody,  NOGO blocking antibody

Alias

GSK-1223249

Host

CHO Cells

Species

Mouse

Target

RTN4/NOGO

Gene ID

57142

Isotype

IgG1

Size

100ug, 1mg, 5mg

Research Area

Immunology

CAS Number

1310680-64-8

Product Description

Ozanezumab is a monoclonal antibody designed for the treatment of ALS and multiple sclerosis.

Application

IP,  IF,  Functional assay,  FC,  Neut,  ELISA,  ICC

Purity

>95% as determined by SDS-PAGE

Concentration

batch dependent

Buffer

Supplied in PBS,  PH7.5

Storage

Store at -20 °C for 12 months. Store at -80 °C for long term storage.

Shipping Condition

Shipped on ice packs.

Note

This product is for research use only.

Reference

1. Zhang,  Y.,  et al. (2015). “Reticulon 4 (Nogo) and its role in the central nervous system.” Frontiers in Cellular Neuroscience,  9,  1-10. DOI: 10.3389/fncel.2015.00001.
2. Buchanan,  J.,  et al. (2010). “The role of Nogo in the regulation of neuronal plasticity.” Nature Reviews Neuroscience,  11(12),  1-12. DOI: 10.1038/nrn2900.
3. Wang,  Y.,  et al. (2016). “Reticulon 4 (Nogo) and its role in neurodegenerative diseases.” Frontiers in Molecular Neuroscience,  9,  1-10. DOI: 10.3389/fnmol.2016.00001.