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ADT1545-Remtolumab Biosimilar-(IL17A/TNFSF2/TNF-alpha/TNFA)-Research Biosimilar Antibody
Antibody

ADT1545-Remtolumab Biosimilar-(IL17A/TNFSF2/TNF-alpha/TNFA)-Research Biosimilar Antibody

  • Catalog Number ADT1545
  • Host CHO Cells
  • Species Human
  • Target TNF alpha/TNFA/IL17A/TNFSF2
  • Application ELISA, WB

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Product Background

TNFA (TNF superfamily member 2, TNFSF2) is located on chromosome 6p21.3. TNF-α is synthesized as a 233-amino acid transmembrane precursor (tmTNF), cleaved by TACE/ADAM17 to release a 157-amino acid soluble homotrimer (sTNF). Binds to TNFR1 (ubiquitous, pro-apoptotic) and TNFR2 (immune/endothelial cells, pro-survival).

Product Specification

Catalog Number

ADT1545

Product Name

ADT1545-Remtolumab Biosimilar-(IL17A/TNFSF2/TNF-alpha/TNFA)-Research Biosimilar Antibody

Clonity

Monoclonal

Alternate Names

anti-mouse IL17A antibody,  anti-IL17A antibody,  anti IL17A antibody,  recombinant IL17A,  IL17A antibody,  anti-IL17A monoclonal antibody,  IL17A antibodies,  IL17A recombinant antibody,  IL17A blocking antibody,  TNFSF2 recombinant antibody,  TNFSF2 blocking antibody,  TNF-alpha recombinant antibody,  TNF-alpha blocking antibody,  TNFA recombinant antibody,  TNFA blocking antibody

Alias

A-1230717,  ABT-122

Host

CHO Cells

Species

Human

Target

TNF alpha/TNFA/IL17A/TNFSF2

Gene ID

7124

Isotype

[VH-VH'-H-Gamma1-VL-VL'-C Kappa]-dimer

Size

1mg, 5mg

Research Area

Immunology

CAS Number

1791410-27-9

Product Description

Remtolumab is under investigation in clinical trial NCT02433340 (Phase 2,  Multicenter,  Open-Label Extension (OLE) Study With ABT-122 in Rheumatoid Arthritis Subjects Who Have Completed the Preceding M12-963 Study).

Application

ELISA,  WB

Purity

>95% as determined by SDS-PAGE

Concentration

batch dependent

Buffer

Supplied in PBS,  PH7.5

Storage

Store at -20 °C for 12 months. Store at -80 °C for long term storage.

Shipping Condition

Shipped on ice packs.

Note

This product is for research use only.

Reference

1. Duan R,  et al. Clin Appl Thromb Hemost,  2023 Jan-Dec. PMID 37229645
2. Wang A,  et al. Med Mycol,  2023 Apr 3. PMID 37055372
3. Yoshii I. J Orthop Sci,  2023 May. PMID 36914483"