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ADT1596-Sofituzumab Biosimilar-(MUC16/CA125)-Research Biosimilar Antibody
Antibody

ADT1596-Sofituzumab Biosimilar-(MUC16/CA125)-Research Biosimilar Antibody

  • Catalog Number ADT1596
  • Host CHO Cells
  • Species Human
  • Target MUC16/CA125
  • Application Elisa, WB

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Product Background

MUC16, a transmembrane mucin encoded by the MUC16 gene, is characterized by a large extracellular domain containing multiple SEA (sea urchin sperm protein, enterokinase, agrin) modules and heavily O-glycosylated tandem repeats, which contribute to its protective and lubricating functions. The extracellular portion, shed as CA125, is a well-established biomarker, while the transmembrane anchor and cytoplasmic tail mediate cell signaling via interactions with ERM (ezrin, radixin, moesin) proteins, linking to the cytoskeleton.

Product Specification

Catalog Number

ADT1596

Product Name

ADT1596-Sofituzumab Biosimilar-(MUC16/CA125)-Research Biosimilar Antibody

Clonity

Monoclonal

Alternate Names

anti MUC16 antibody,  MUC16 monoclonal antibody,  human CA125 antibody,  CA125 antibody,  anti Mucin 16 antibody,  anti-mouse MUC16 antibody,  anti-MUC16 antibody,  anti MUC16 antibody,  recombinant MUC16,  MUC16 antibody,  anti-MUC16 monoclonal antibody,  MUC16 antibodies,  MUC16 recombinant antibody,  MUC16 blocking antibody,  CA125 recombinant antibody,  CA125 blocking antibody

Alias

MAB-B43.13,  oregovamab

Host

CHO Cells

Species

Human

Target

MUC16/CA125

Gene ID

94025

Isotype

IgG1 Kappa

Size

100ug, 1mg, 5mg

Research Area

Cancer

CAS Number

213327-37-8

Product Description

Oregovomab is a mouse monoclonal antibody it binds to the antigen CA125,  a carbohydrate antigen.

Mechanism of Action

Oregovomab is a monoclonal antibody targeting the CA-125 antigen,  which is associated with ovarian cancer.

Metabolism

Oregovomab has a long half-life and is distributed throughout the bloodstream and tissues.

Application

Elisa,  WB

Purity

>95% as determined by SDS-PAGE

Concentration

batch dependent

Buffer

Supplied in PBS,  PH7.5

Storage

Store at -20 °C for 12 months. Store at -80 °C for long term storage.

Shipping Condition

Shipped on ice packs.

Note

This product is for research use only.

Reactivity

Human

Reference

1. Plana A,  et al. Acta Oncol,  2023 May. PMID 37129994
2. Yamashita T,  et al. Am J Pathol,  2023 Mar. PMID 36586479
3. Ferrer VP. Cancer Genet,  2023 Jan. PMID 36436416