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ADT1689-Vanucizumab Biosimilar-(ANGPT2/VEGFA)-Research Biosimilar Antibody
Antibody

ADT1689-Vanucizumab Biosimilar-(ANGPT2/VEGFA)-Research Biosimilar Antibody

  • Catalog Number ADT1689
  • Host CHO Cells
  • Species Human
  • Target ITGA2
  • Application WB, FC, IP, ELISA, Neut, Functional assay, IF

We conduct stability studies under different storage conditions and evaluate immune responses to ensure the effectiveness of biosimilars when used in research.

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Product Background

ANGPT2, a member of the angiopoietin family, primarily modulates vascular stability and permeability by interacting with the Tie2 receptor on endothelial cells. It acts as a context-dependent agonist/antagonist: in stable vasculature, ANGPT2 antagonizes Tie2 signaling to destabilize blood vessels, enabling responsiveness to pro-angiogenic signals like VEGFA.

Product Specification

Catalog Number

ADT1689

Product Name

ADT1689-Vanucizumab Biosimilar-(ANGPT2/VEGFA)-Research Biosimilar Antibody

Clonity

Monoclonal

Alternate Names

anti-mouse ANGPT2 antibody,  anti-ANGPT2 antibody,  anti ANGPT2 antibody,  recombinant ANGPT2,  ANGPT2 antibody,  anti-ANGPT2 monoclonal antibody,  ANGPT2 antibodies,  ANGPT2 recombinant antibody,  ANGPT2 blocking antibody,  VEGFA recombinant antibody,  VEGFA blocking antibody

Alias

RG-7221,  RG7221,  RO5520985

Host

CHO Cells

Species

Human

Target

VEGFA/ANGPT2

Gene ID

285

Isotype

VH-C Kappa-CH2-CH3_V Lambda-CH1_H-GAMMA-1_L Kappa

Size

1mg, 5mg

Research Area

Cancer

CAS Number

1448221-05-3

Product Description

Vanucizumab (INN,  development code RG7221) is an experimental humanized monoclonal antibody designed for the treatment of cancer.

Application

WB,  FC,  IP,  ELISA,  Neut,  Functional assay,  IF

Purity

>95% as determined by SDS-PAGE

Concentration

batch dependent

Buffer

Supplied in PBS,  PH7.5

Storage

Store at -20 °C for 12 months. Store at -80 °C for long term storage.

Shipping Condition

Shipped on ice packs.

Note

This product is for research use only.

Reference

1. Wang B,  et al. Genet Test Mol Biomarkers,  2023 Jun. PMID 37382908
2. Kawagishi N,  et al. Viruses,  2023 Jan 7. PMID 36680221
3. Yang S,  et al. Front Immunol,  2022. PMID 36172371