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ADT1723-Zansecimab Biosimilar-(ANGPT2)-Research Biosimilar Antibody
Antibody

ADT1723-Zansecimab Biosimilar-(ANGPT2)-Research Biosimilar Antibody

  • Catalog Number ADT1723
  • Host CHO Cells
  • Species Mouse
  • Target ANGPT2
  • Application ELISA, FCM, BLI, SPR, Functional assay

We conduct stability studies under different storage conditions and evaluate immune responses to ensure the effectiveness of biosimilars when used in research.

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Product Background

ANGPT2, a member of the angiopoietin family, primarily modulates vascular stability and permeability by interacting with the Tie2 receptor on endothelial cells. It acts as a context-dependent agonist/antagonist: in stable vasculature, ANGPT2 antagonizes Tie2 signaling to destabilize blood vessels, enabling responsiveness to pro-angiogenic signals like VEGFA.

Product Specification

Catalog Number

ADT1723

Product Name

ADT1723-Zansecimab Biosimilar-(ANGPT2)-Research Biosimilar Antibody

Alternate Names

anti-mouse ANGPT2 antibody, anti-ANGPT2 antibody, anti ANGPT2 antibody, recombinant ANGPT2, ANGPT2 antibody, anti-ANGPT2 monoclonal antibody, ANGPT2 antibodies, ANGPT2 recombinant antibody, ANGPT2 blocking antibody

Clonity

Monoclonal

Host

CHO Cells

Species

Mouse

Target

ANGPT2

Isotype

IgG4SP Kappa

Size

100ug, 1mg, 5mg

Research Area

Immunology

CAS Number

2415205-37-5

Product Description

Anti-ANGPT2 Reference Antibody (zansecimab) is expressed from CHO. The heavy chain type is huIgG4SP, and the light chain type is kappa. It has a predicted MW of 145.5 kDa.

Molecular Weight

145.5 KDa

Application

ELISA, Flow Cytometry, Kinetics (BLI), Kinetics (SPR), Functional assay

Purity

>95% as determined by SDS-PAGE

Concentration

batch dependent

Buffer

Supplied in PBS, PH7.5

Storage

Store at -20 °C for 12 months. Store at -80 °C for long term storage.

Shipping Condition

Shipped on ice packs.

Note

This product is for research use only.

Reference

1. "Angiopoietin-2 as a therapeutic target in cancer and inflammation" (DOI: 10.1016/j.drudis.2018.10.014)
2. "ANGPT2 inhibition suppresses tumor growth and angiogenesis in preclinical models" (PubMed ID: 30531912)
3. "Role of ANGPT2 in vascular permeability and sepsis" (PMCID: PMC7008762)