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Product Background
Catalog Number |
ADT1754 |
Product Name |
ADT1754-Human Anti-CD3xClaudin18.2 Bispecific Antibody |
Isotype |
ScFv-ScFc |
Clonity |
Monoclonal |
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Alternate Names Human Anti-CD3 mAb, Anti-CD3 Monoclonal Antibody, CD3 recombinant antibody, Anti-CD3 Bispecific Antibody, Human Anti-Claudin18.2 mAb, Claudin18.2 recombinant antibody, Anti-Claudin18.2 Monoclonal Antibody, Anti-Claudin18.2 Bispecific Antibody |
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Official Symbol |
CD3xClaudin18.2 |
Target 1 |
CD3 |
Gene ID 1 |
916 |
Target 2 |
Claudin18.2 |
Species |
Human |
Drug Name |
Gresonitamab |
Endotoxin |
<1EU/mg. Determined by the LAL method. |
Sterility |
0.2 μM filtered. |
Expression Host |
CHO Cells |
CAS Number |
2413817-97-5 |
Size |
1mg,5mg,50mg,100mg |
Research Area |
Cancer |
Application |
FuncS |
Purity |
>90% |
Concentration |
Batch dependent |
Buffer |
Supplied in PBS, pH 7.4,Contains no stabilizers or preservatives |
Recommended Dilution Buffer |
ABDB-1002 or PBS, pH 7.4, Contains no stabilizers or preservatives. |
Storage |
2 weeks, 2-8℃ under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for one-year storage. |
Shipping Condition |
Shipped on ice packs. |
Protocol Information |
Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose-response or titration experiment. |
Note |
For Research Use Only! |
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Reference 1. Van Der Stegen et al. (2015). Nat Protoc. DOI: 10.1038/nprot.2015.035
2. Sahin et al. (2008). Clin Cancer Res. DOI: 10.1158/1078-0432.CCR-08-0073
3. Türeci et al. (2021). Nat Med. DOI: 10.1038/s41591-021-01344-3
4. Jiang et al. (2022). J Clin Oncol. DOI: 10.1200/JCO.21.02010
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FAQ
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Can bispecific antibodies penetrate solid tumors?
Smaller formats (e.g., BiTEs) penetrate better but have shorter half-lives. Larger IgG-like BsAbs may rely on enhanced permeability or combination therapies.
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How can I obtain COA of the reagent that I received?
Please contact us via email info@alphalifetech.com for detailed information about the product.
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How are bispecific antibodies evaluated in preclinical studies?
Assays include binding affinity (SPR/BLI), cell-based cytotoxicity, pharmacokinetics, and toxicity profiling in animal models. -
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What is Claudin18.2?
A tight junction protein overexpressed in gastric, pancreatic, and lung cancers, making it a tumor-specific target.