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- info@alphalifetech.com
- 90 State Street, STE 700 Office 40, Albany, NY 12207 United States
Product Background
Catalog Number |
ADT1755 |
Product Name |
ADT1755-Human Anti-CTLA4xLAG3 Bispecific Antibody |
Isotype |
Half-IgG1-scFv-kappa -Human IgG1CH2-CH3 |
Clonity |
Monoclonal |
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Alternate Names Human Anti-CTLA4 mAb, Anti-CTLA4 Monoclonal Antibody, CTLA4 recombinant antibody, Anti-CTLA4 Bispecific Antibody, Human Anti-LAG3 mAb, LAG3 recombinant antibody, Anti-LAG3 Monoclonal Antibody, Anti-LAG3 Bispecific Antibody |
|
Official Symbol |
CTLA-4xLAG3 |
Target 1 |
CTLA-4 |
Gene ID 1 |
1493 |
Target 2 |
LAG3 |
Gene 2 |
3902 |
Species |
Human |
Drug Name |
Bavunalimab |
Endotoxin |
<1EU/mg. Determined by the LAL method. |
Sterility |
0.2 μM filtered. |
Expression Host |
CHO Cells |
Size |
1mg,5mg,50mg,100mg |
Research Area |
Cancer |
Application |
FuncS |
Purity |
>90% |
Concentration |
Batch dependent |
Buffer |
Supplied in PBS, pH 7.4,Contains no stabilizers or preservatives |
Recommended Dilution Buffer |
ABDB-1002 or PBS, pH 7.4, Contains no stabilizers or preservatives. |
Storage |
2 weeks, 2-8℃ under sterile conditions after reconstitution. Avoid repeated freeze-thaw. -80°C for one-year storage. |
Shipping Condition |
Shipped on ice packs. |
Protocol Information |
Since applications vary, each investigator should use the application references as a guide to help estimate the appropriate dose or concentration. The dose or concentration can be further optimized experimentally in a dose-response or titration experiment. |
Note |
For Research Use Only! |
|
Reference 1. Leach et al. (1996). Science. DOI: 10.1126/science.272.5260.1737
2. Hodi et al. (2010). NEJM. DOI: 10.1056/NEJMoa1003466
3. Triebel et al. (1990). J Exp Med. DOI: 10.1084/jem.171.5.1393
4. Woo et al. (2012). Cancer Res. DOI: 10.1158/0008-5472.CAN-11-3909
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FAQ
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What future trends are shaping bispecific antibody development?
Trends include multi-specific antibodies (>2 targets), improved tissue penetration, "off-the-shelf" formats, and combinations with CAR-T, vaccines, or small molecules.
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How can I obtain COA of the reagent that I received?
Please contact us via email info@alphalifetech.com for detailed information about the product.
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What is LAG3?
Lymphocyte-activation gene 3 (LAG3) suppresses T-cell function. Dual inhibition with CTLA-4 amplifies immune activation. -
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What are bispecific antibodies (BsAbs)?
A bispecific antibody (BsAb) is an engineered antibody capable of binding two distinct antigens or epitopes simultaneously, enabling novel therapeutic mechanisms not achievable with monoclonal antibodies.