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AFP111-Liraglutide
Isotype Control Antibodies

AFP111-Liraglutide

  • Catalog Number AFP111
  • Molecular Formula C₁₇₂H₂₆₅N₄₃O₅₁
  • Purity >98%
  • Purification HPLC
  • Endotoxin < 5 EU/mg

Liraglutide is a long-acting analogue of human GLP-1 with 97% sequence homology to the endogenous peptide. The molecule is engineered with two primary modifications: the substitution of lysine with arginine at position 34 and the attachment of a C16 fatty acid (palmitic acid) side chain via a glutamic acid spacer at position 26. These structural changes enable the molecule to bind non-covalently to serum albumin and resist degradation by the dipeptidyl peptidase-4 (DPP-4) enzyme, resulting in a significantly extended half-life suitable for once-daily administration.

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Product Background

Functionally, Liraglutide acts as a potent GLP-1 receptor agonist that regulates appetite and energy intake. It targets specific areas in the hypothalamus to increase satiety signals and decrease hunger signals, leading to a reduction in total body weight. Beyond its metabolic effects on adipose tissue and appetite, it provides sustained glycemic control by enhancing beta-cell function and modulating gastric transit time, making it a standard therapeutic option for chronic weight management.

Product Specification

Catalog Number

AFP111

Product Name

AFP111-Liraglutide

Molecular Formula

C₁₇₂H₂₆₅N₄₃O₅₁

Molecular Weight

3751.2 Da

Structural formula

H-H-A-E-G-T-F-T-S-D-V-S-S-Y-L-E-G-Q-A-A-K(γGlu-C16 acyl)
-E-F-I-A-W-L-V-R-G-R-OH

CAS Accession

204656-20-2

Size

1mg, 5mg, 100mg, bulk

Storage Condition

Cool dry place(-20±5℃,Keep away from acids and alkali)

Purity

>98%

Purification

HPLC

Endotoxin

< 5 EU/mg

Reconstitution Conditions

Reconstitute in ddH₂O for a stock solution.

Shipping Condition

This product is shipped on ice packs.

Note

For Research Use Only!