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AFP112-Semaglutide
Isotype Control Antibodies

AFP112-Semaglutide

  • Catalog Number AFP112
  • Molecular Formula C₁₈₇H₂₉₁N₄₅O₅₉
  • Purity >98%
  • Purification HPLC
  • Endotoxin < 5 EU/mg

Semaglutide is an ultra-long-acting GLP-1 receptor agonist designed for high potency and prolonged duration of action. Its structure includes a substitution of alpha-aminoisobutyric acid (Aib) at position 8 to provide metabolic stability against DPP-4, and the attachment of a C18 fatty diacid chain via a hydrophilic linker at position 26. These modifications markedly increase its affinity for albumin, allowing for a half-life of approximately 165 hours, which supports a once-weekly subcutaneous dosing regimen.

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Product Background

In addition to its role in glycemic regulation, Semaglutide demonstrates high efficacy in weight reduction by crossing the blood-brain barrier to target satiety centers. It effectively lowers the "set point" for body weight by reducing energy intake and food cravings. By modulating both the homeostatic and hedonic pathways of eating behavior, Semaglutide provides a robust physiological approach to treating obesity and its associated metabolic comorbidities.

Product Specification

Catalog Number

AFP112

Product Name

AFP112-Semaglutide

Molecular Formula

C₁₈₇H₂₉₁N₄₅O₅₉

Molecular Weight

4113.58 Da

Structural formula

H-H-Aib-Q-G-T-F-T-S-N-Y-S-Y-L-E-K(AEEA-AEEA-γGlu-C18 diacid)
-A-Q-Aib-A-F-I-E-Y-L-L-E-G-G-P-S-S-G-A-P-P-P-S-NH2

CAS Accession

910463-68-2

Size

1mg, 5mg, 100mg, bulk

Storage Condition

Cool dry place(-20±5℃,Keep away from acids and alkali)

Purity

>98%

Purification

HPLC

Endotoxin

< 5 EU/mg

Reconstitution Conditions

Reconstitute in ddH₂O for a stock solution.

Shipping Condition

This product is shipped on ice packs.

Note

For Research Use Only!