ANGPTL4/Angiopoietin-like Protein 4
Alpha Lifetech can provide ANGPTL4 corresponding products, help each customer's research and development.
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Introduction to ANGPTL4/Angiopoietin-like Protein 4
Drug targets a biomolecule that can directly bind to drugs and then react. Generally, the target refers to a protein, which is related to the cause of disease. The focus of the target began with focusing on tumors and then began to spread to various fields. Introduction to CD160 protein is a common target in medicine.
Function of Target ANGPTL4/Angiopoietin-like Protein 4
The ANGPTL4 protein is involved in the signaling pathway of PI3K / Akt in delaying apoptosis on this pathway. In particular, under extreme ischemia/hypoxia, ANGPTL4 is able to signal the contact between mesenchymal stem cells and the extracellular matrix, thus promoting the probability of cell survival in extreme environments.ANGPTL4 also participates in the signaling pathway of ERK 1 / 2 (extracellular regulatory protein kinase 1 / 2), which plays a huge role in the growth process of cell proliferation, differentiation, and apoptosis.ANGPTL4 proteins can also activate ERK 1 / 2 in a now unknown way, then affect the interaction between ANGPTL4 proteins and integrins, and finally form a related complex, and then initiate downstream signaling pathways. Integrin is one of the related receptors of the extracellular matrix and plays a special role between the body cells and the matrix. In addition, the ANGPTL4 protein can also participate in the regulation of other signaling pathways. For example, studies have shown that ANGPTL4 protein is related to iron death signaling, and ANGPTL4 protein may help the body fight tumors by blocking iron death.ANGPTL4 can affect the transport and distribution of fat in the blood of the body, and then have a profound impact on the balance of the whole body. Increasing or decreasing ANGPTL4 protein can affect the body's glucose metabolism and insulin, thus changing the metabolic environment of the body.
Gene Pathway of Target ANGPTL4/Angiopoietin-like Protein 4
The ANGPTL4 protein is involved in the signaling pathway of PI3K / Akt in delaying apoptosis on this pathway. In particular, under extreme ischemia/hypoxia, ANGPTL4 is able to signal the contact between mesenchymal stem cells and the extracellular matrix, thus promoting the probability of cell survival in extreme environments.ANGPTL4 also participates in the signaling pathway of ERK 1 / 2 (extracellular regulatory protein kinase 1 / 2), which plays a huge role in the growth process of cell proliferation, differentiation, and apoptosis.ANGPTL4 proteins can also activate ERK 1 / 2 in a now unknown way, then affect the interaction between ANGPTL4 proteins and integrins, and finally form a related complex, and then initiate downstream signaling pathways. Integrin is one of the related receptors of the extracellular matrix and plays a special role between the body cells and the matrix. In addition, the ANGPTL4 protein can also participate in the regulation of other signaling pathways. For example, studies have shown that ANGPTL4 protein is related to iron death signaling, and ANGPTL4 protein may help the body fight tumors by blocking iron death.ANGPTL4 can affect the transport and distribution of fat in the blood of the body, and then have a profound impact on the balance of the whole body. Increasing or decreasing ANGPTL4 protein can affect the body's glucose metabolism and insulin, thus changing the metabolic environment of the body.
Fig 1: ANGPTL4 Gene Pathway. (Reference documentation: Kersten S. Role and mechanism of the action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism. J Lipid Res. 2021;62:100150. )
Alpha Lifetech Can Provide
| Catalog Number | Product Name | Product Sizes |
|---|---|---|
| ALP64538 | 50ug,100ug,500ug | |
Reference
[1] Aryal B, Price NL, Suarez Y, Fernández-Hernando C. ANGPTL4 in Metabolic and Cardiovascular Disease. Trends Mol Med. 2019 Aug;25(8):723-734.
[2] Fernández-Hernando C, Suárez Y. ANGPTL4: a multifunctional protein involved in metabolism and vascular homeostasis. Curr Opin Hematol. 2020 May;27(3):206-213.
[3] Cho DI, Ahn MJ, Cho HH, Cho M, Jun JH, Kang BG, Lim SY, Yoo SJ, Kim MR, Kim HS, Lee SJ, Dat LT, Lee C, Kim YS, Ahn Y. ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation. Exp Mol Med. 2023 Feb;55(2):426-442.
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2018-07-16
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