Introduction To CD150/SLAM
Drug targets a biomolecule that can directly bind to drugs and then react. Generally, the target refers to a protein, which is related to the cause of disease. The focus of the target began with focusing on tumors, and then began to spread to various fields .CD150/SLAM protein is a common target in medicine.
CD150 is also known as the signaling lymphocyte-activating molecule, SLAM. CD150 is also the most common receptor of the genus measles virus, which is a membrane glycoprotein expressed on host immune cells and has immune specificity to the genus measles virus. CD150 is a single-stranded phosphoglycoprotein, which includes two already highly glycosylated immunoglobulin superfamily domains, a member of the CD2 family, and like other members, CD150 has two extracellular domains: the N-terminal membrane-distal type V set and the juxtamembrane C2 type set. CD150 is also a molecular protein that can bind itself to produce costimulators. It activates T cells, B lymphocytes, dendritic cells, and macrophages and rapidly these cells to differentiate. CD150 is also a molecular protein that can bind itself to produce costimulators. It activates T cells, B lymphocytes, dendritic cells, and macrophages and rapidly these cells to differentiate. CD150 As a viral receptor is a good explanation of why the host has immune suppression and other phenomena after the virus infection.
Function of Target CD150/SLAM
CD150 can change the state of immune cells by affecting the innate and adaptive immune responses generated by the body. Whether CD150 protein has specific activity mainly depends on the presence of adaptor protein. In T cells and B cells, CD150 can induce various types of signaling pathways, and CD150 can make IL-2-independent T cells undergo proliferation, IFN- γ production, and activation of downstream signaling pathways.
CD150 can help complete the differentiation of helper T cells (Tfh), acting together when the body responds to foreign materials. At the same time, as a receptor for the virus, CD150 also completes the process of virus infection of the body. High-level expression of CD150 occurs on B cells, and the interaction with CD8 + T cells may lead to T cell loss, which attenuates the tumor inhibition.
Gene Pathway of Target CD150/SLAM
Signal transduction of CD150 in the immune response involves multiple signaling pathways and molecules. The CD150 activity is regulated by the cytoplasmic adaptor protein. These adaptor proteins play a key role in the signaling by CD150. In T cells, CD150 produces two kinds of signals: one dependent on SH2D1A (and possibly SH2D1B), and the other dependent on protein tyrosine phosphatase 2C (PTPN11). These signals are involved in the downstream signaling pathways of INPP5D, DOK 1, DOK 2, PRKCQ, BCL 10, and NFKB 1.

Fig 1: CD150 Gene Pathway. (Reference source: Gordiienko I, Shlapatska L, Kovalevska L, Sidorenko SP. SLAMF1/CD150 in hematologic malignancies: Silent marker or active player? Clin Immunol. 2019 Jul;204:14-22. )
Alpha Lifetech Can Provide
| Catalog Number | Product Name | Product Sizes |
|---|---|---|
| ALP64687 | 50ug,100ug,500ug | |
| ALP64628 | 50ug,100ug,500ug | |
Reference
[1] Khosravi M, Bringolf F, Röthlisberger S, Bieringer M, Schneider-Schaulies J, Zurbriggen A, Origgi F, Plattet P. Canine Distemper Virus Fusion Activation: Critical Role of Residue E123 of CD150/SLAM. J Virol. 2015 Nov 25;90(3):1622-37.
[2] Gordiienko I, Shlapatska L, Kovalevska L, Sidorenko SP. SLAMF1/CD150 in hematologic malignancies: Silent marker or active player? Clin Immunol. 2019 Jul;204:14-22.
[3] Guselnikov SV, Laktionov PP, Najakshin AM, Baranov KO, Taranin AV. Expansion and diversification of the signaling capabilities of the CD2/SLAM family in Xenopodinae amphibians. Immunogenetics. 2011 Oct;63(10):679-89.
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