CD172a/SHPS-1/SIRPA
Alpha Lifetech can provide CD172a/SHPS-1/SIRPA corresponding products, help each customer's research and development.
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Introduction To CD172a/SHPS-1/SIRPA
Drug targets a biomolecule that can directly bind to drugs and then react. Generally, the target refers to a protein, which is related to the cause of disease. The focus of the target began with focusing on tumors and then began to spread to various fields. Introduction to CD172a/SHPS-1/SIRPA protein is a common target in medicine.
The signal regulatory protein α is also known as CD172a, PTPNS1, MFR, p84, BIT, SHPS-1, and SIRP α is a typical inhibitory immune receptor in the SIRP family, expressed by leukocyte subsets such as monocytes and lymphocytes. SIRP α is a transmembrane protein with an extracellular N terminus, transmembrane region, and intracellular C terminus. The extracellular portion of SIRP α can be involved in cell-cell interactions. SIRP α is a cell surface receptor expressed primarily by myeloid cells that recognizes the progenitors of the cardiomyocyte lineage differentiated from hiPSCs cells.
Function of Target CD172a/SHPS-1/SIRPA
CD172a Can bind to the ligand CD47 to prevent macrophages from phagocyting healthy cells, and cancer cells can also use this opportunity to escape the immune system clearance. Some low doses of anti-SIRP α antibodies can block the CD47-SIRP α signaling pathway in tumor cells. At the same time, SIRP α binds to the ligand CD47, and can also participate in cell-cell adhesion to maintain the structure and function of tissues and organs. In neurons, SIRP α supports the adhesion of cerebellar neurons, neurite outgrowth, and the attachment of glial cells. The ding of CD47 to SIRP α can transmit inhibitory signals, hinder macrophage phagocytosis and activation of dendritic cells, and then control the immune response. By working with growth factor receptors, SIRP α can alter cell growth and evolution.
Gene Pathway of Target CD172a/SHPS-1/SIRPA
SIRP signaling occurs when CD47 α. These transduction involve partial intracellular phosphorylation of SIRP α, conformational changes, and effects with other signaling molecules. Ultimately, this signaling can inhibit macrophage phagocytosis and activation of dendritic cells, thereby controlling the immune response. In addition to the CD47-SIRP α signaling pathway, SIRP α may also be involved in the regulation of other signaling pathways. How these signaling pathways affect the body also needs to be explored in depth.
Fig 1: CD47-SIRPα Gene Pathway. (Reference source: Matlung HL, Szilagyi K, Barclay NA, van den Berg TK. The CD47-SIRPα signaling axis as an innate immune checkpoint in cancer. Immunol Rev. 2017 Mar;276(1):145-164. )
Alpha Lifetech Can Provide
| Catalog Number | Product Name | Product Sizes |
|---|---|---|
| ALP64700 | 50ug,100ug,500ug | |
| ALP64689 | 50ug,100ug,500ug | |
| ALP64600 | 50ug,100ug,500ug | |
| ALP64599 | 50ug,100ug,500ug | |
| ALP64598 | 50ug,100ug,500ug | |
| ALP64521 | 50ug,100ug,500ug | |
| ALP64516 | 50ug,100ug,500ug | |
| ALP64510 | 50ug,100ug,500ug | |
Reference
[1] Verjan Garcia N, Umemoto E, Saito Y, Yamasaki M, Hata E, Matozaki T, Murakami M, Jung YJ, Woo SY, Seoh JY, Jang MH, Aozasa K, Miyasaka M. SIRPα/CD172a regulates eosinophil homeostasis. J Immunol. 2011 Sep 1;187(5):2268-77.
[2] Baba N, Van VQ, Wakahara K, Rubio M, Fortin G, Panzini B, Soucy G, Wassef R, Richard C, Tamaz R, Lahaie R, Bernard EJ, Caussignac Y, Leduc R, Lougnarath R, Bergeron C, Racicot MA, Bergeron F, Panzini MA, Demetter P, Franchimont D, Schäkel K, Weckbecker G, Kolbinger F, Heusser C, Huber T, Welzenbach K, Sarfati M. CD47 fusion protein targets CD172a+ cells in Crohn's disease and dampens the production of IL-1β and TNF. J Exp Med. 2013 Jun 3;210(6):1251-63.
[3] Matlung HL, Szilagyi K, Barclay NA, van den Berg TK. The CD47-SIRPα signaling axis is an innate immune checkpoint in cancer. Immunol Rev. 2017 Mar;276(1):145-164.
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2018-07-16
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