CD24
Alpha Lifetech can provide CD24 corresponding products, help each customer's research and development.
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Introduction To CD24
A drug targets a biomolecule that can directly bind to drugs and then react. Generally, the target refers to a protein, which is related to the cause of disease. The focus of the target began with focusing on tumors and then began to spread to various fields. Introduction to CD24 protein is a common target in medicine.
Cluster of differentiation 24, CD24 is a heavily glycosylated GPI-anchored membrane protein and a small, highly glycosylated cell adhesion protein, also known as thermostable antigen because of its thermostable carbohydrate structure. The human CD24 gene is a very short peptide with 31 amino acids that is homologous to mouse CD24a or heat stable antigen (HSA). CD24 is a short mucoid protein that is highly glycosylated, and its peptide backbone contains multiple sites for N-and O-glycosylation. CD24 has no transmembrane domain and is anchored to the cell membrane by glycosyl-phosphatidyl-inositol.
Function of Target CD24
CD24 can interfere with tumor cell mRNA stability, cell adhesion, growth, proliferation, invasion, and metastasis, as well as inhibit tumor cell apoptosis. CD24 is a potential prognostic marker for many types of tumors, and cytoplasmic / membrane expression of CD24 helps define patients with low or high risk of recurrence; in bladder cancer, up-regulation of CD24 in the cytoplasm is involved in the more aggressive cancer development process and tumor recurrence. Meanwhile, inhibition of NF 2-YAP can downregulate the expression of iron death inhibitor protein 1 (FSP 1) and CD24 in cells with high CD24 expression, thus promoting cell iron death and macrophages.
Gene Pathway of Target CD24
CD24 promotes the growth and proliferation of tumor cells by activating the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue homeostasis, and pathogenesis, and its aberrant activation is closely related to the development of various tumors. CD24 also promotes the growth and proliferation of tumor cells by activating the MAPK signaling pathway (mitogen-activated protein kinase signaling pathway). MAPK signaling pathway is one of the important systems of signal transduction in cells, involved in the regulation of various physiological processes such as cell growth, differentiation, and apoptosis. In some types of tumor cells (such as colorectal cancer cells), CD24 also mediates survival autophagy through the activation of the NF- κ B signaling pathway. NF- κ B is an important transcription factor involved in the regulation of various physiological processes including inflammatory response, immune response, cell proliferation, and apoptosis.
Fig 1: CD24 Gene Pathway. (Reference source: Barkal AA, Brewer RE, Markovic M, Kowarsky M, Barkal SA, Zaro BW, Krishnan V, Hatakeyama J, Dorigo O, Barkal LJ, Weissman IL. CD24 signaling through macrophage Siglec-10 is a target for cancer immunotherapy. Nature. 2019 Aug;572(7769):392-396. )
Alpha Lifetech Can Provide
| Catalog Number | Product Name | Product Sizes |
|---|---|---|
| ALP64505 | 50ug,100ug,500ug | |
Reference
[1] Barkal AA, Brewer RE, Markovic M, Kowarsky M, Barkal SA, Zaro BW, Krishnan V, Hatakeyama J, Dorigo O, Barkal LJ, Weissman IL. CD24 signaling through macrophage Siglec-10 is a target for cancer immunotherapy. Nature. 2019 Aug;572(7769):392-396.
[2] Liu Y, Zheng P. CD24-Siglec interactions in inflammatory diseases. Front Immunol. 2023 May 9;14:1174789.
[3] Ni YH, Zhao X, Wang W. CD24, A Review of its Role in Tumor Diagnosis, Progression and Therapy. Curr Gene Ther. 2020;20(2):109-126.
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2018-07-16
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