CD252/OX40L/TNFSF4
Alpha Lifetech can provide CD252/OX40L/TNFSF4 corresponding products, help each customer's research and development.
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Introduction To CD252/OX40L/TNFSF4
Drug targets a biomolecule that can directly bind to drugs and then react. Generally, the target refers to a protein, which is related to the cause of disease. The focus of the target began with focusing on tumors, and then began to spread to various fields. Introduction to CD252/OX40L/TNFSF4 protein is a common target in medicine.
OX40 L, also known as CD252, TNFSF4, CD134L, or gp 34, is a ligand for OX40. Is a type II glycoprotein that expresses in a trimeric form and is a member of the TNF superfamily. OX 40 L is mostly expressed on the surface of antigen-presenting cells (APCs). In addition to the surface of B cells, dendritic cells (DC), and macrophages, OX40 L is also expressed on NK, mast cells, smooth muscle cells, and vascular endothelial cells. Similar to the other members of the TNF family, the OX 40 signal is transduced through TRAF.
Function of Target CD252/OX40L/TNFSF4
The interaction between OX 40 and OX 40 L will affect the body, which will lead to the proliferation of B cells and antibody secretion, It can also affect the proliferation and differentiation of the primary T cells and enhance the survival rate of the T cells.OX 40 / OX 40 L has different effects on different classes of T cells. Blocking OX 40 / OX 40 L improves self-antigen-specific T-cell responses and reduces immune activity in autoimmune diseases.
Gene Pathway of Target CD252/OX40L/TNFSF4
OX40L is a hexamer complex, which is composed of a trimer and three OX40 proteins, which affect the genes of T cell division and survival by activating downstream NF-κB, PI3K, and AKT signaling pathways, and further promote the transcription of cytokine genes and the expression of cytokine receptors, which is very important for cell survival.
OX40 L and mutual influence between 40, TNFR related (TRAFs) can affect CD4 + T cell tolerance to the regulation of the OX 40 intracellular domain, TRAF family activate NF- κ B and other signaling pathways, cause the effector T cells and prolong survival time, inhibit the differentiation and activity of regulatory T cells, promote and maintain CD4 + cell memory, promote the generation of memory CD8 + cells, interact with a variety of pro-inflammatory mediators, improve autoimmunity in the body.
If we block the binding of OX 40 to OX 40 L, we can change the antigen-specific T cell response produced by the body itself and reduce the immune activity of the self-free disease. Therefore, OX 40 / OX 40 L inhibitors have therapeutic potential for autoimmune diseases.
Fig 1: OX40L Gene Pathway. (Reference source: Thapa B, Kato S, Nishizaki D, Miyashita H, Lee S, Nesline MK, Previs RA, Conroy JM, DePietro P, Pabla S, Kurzrock R. OX40/OX40 ligand and its role in precision immune oncology. Cancer Metastasis Rev. 2024 Sep;43(3):1001-1013. )
Alpha Lifetech Can Provide
At present, various drugs targeting CD252/OX40L/TNFSF4 are constantly under development, and taking drugs alone or together with other products to treat diseases has become a new method and remarkable achievements have been made. CD252/OX40L/TNFSF4 protein has shown important research value and application prospects in tumor biology, and drug research and development. With further research and technological advances, CD252/OX40L/TNFSF4 protein products are also essential. Alpha Lifetech can provide CD252/OX40L/TNFSF4 corresponding products and help each customer's research and development. In addition, Alpha Lifetech can provide efficient and accurate EC50 / IC50, helping customer companies to screen compounds efficiently and accurately. At the same time, Alpha Lifetech also provides some services such as recombinant antibody production and recombinant antibody purification, to conduct in vitro affinity screening to ensure the maturity of recombinant antibody affinity and help customers in antibody drug discovery, and subsequent various experiments.
| Catalog Number | Product Name | Product Sizes |
|---|---|---|
| ALP64684 | 50ug,100ug,500ug | |
| ALP64621 | 50ug,100ug,500ug | |
| ALP64597 | 50ug,100ug,500ug | |
| ALP64549 | 50ug,100ug,500ug | |
Reference
[1] Gonzalez Roldan N, Orinska Z, Ewers H, Bulfone-Paus S. CD252 regulates mast cell mediated, CD1d-restricted NKT-cell activation in mice. Eur J Immunol. 2016 Feb;46(2):432-9.
[2] Walch M, Rampini SK, Stoeckli I, Latinovic-Golic S, Dumrese C, Sundstrom H, Vogetseder A, Marino J, Glauser DL, van den Broek M, Sander P, Groscurth P, Ziegler U. Involvement of CD252 (CD134L) and IL-2 in the expression of cytotoxic proteins in bacterial- or viral-activated human T cells. J Immunol. 2009 Jun 15;182(12):7569-79.
[3] Thapa B, Kato S, Nishizaki D, Miyashita H, Lee S, Nesline MK, Previs RA, Conroy JM, DePietro P, Pabla S, Kurzrock R. OX40/OX40 ligand and its role in precision immune oncology. Cancer Metastasis Rev. 2024 Sep;43(3):1001-1013.
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2018-07-16
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