CD275 has a dual role as a co-stimulatory / co-inhibitory immune checkpoint molecule. ICOS-L can undergo co-stimulation by binding with CD28. ICOS may play a role in maintaining durable immune responses and is expressed at particularly high levels in reproductive central T cells or TFH. ICOS-L is constitutively expressed by APC as well as multiple nonhematopoietic stem cells. Earlier studies showed that CD275 can stimulate CD4 + and CD8 + T cell proliferation and IFN-γ production, but more recent work suggests that CD275 can reduce IFN-γ and IL-4 expression by inhibiting NFAT, NF-Bᴋ, and AP-1 pathways, inactivating T cell receptor signaling.CD275 is also involved in regulating the polarization and function of immune cells, such as promoting the activity of Tregs (regulatory T cells) and M2 polarization (anti-inflammatory macrophages) while inhibiting the activity of NK cells and CD8 + T cells, which is conducive to immune evasion and pro-tumorigenic phenotype. CD275 expression is dysregulated in multiple malignancies and is associated with a more aggressive disease course and a poorer outcome. In addition to immune function, CD275 is also expressed on osteoblasts and adipocyte progenitors and is involved in the regulation of skeletal growth and adipocyte differentiation.

At present, various drugs targeting CD275/B7-H2/ICOSL are constantly under development, and taking drugs alone or together with other products to treat diseases has become a new method and remarkable achievements have been made. CD275/B7-H2/ICOSL protein has shown important research value and application prospects in tumor biology, and drug research and development. With further research and technological advances, CD275/B7-H2/ICOSL protein products are also essential. Alpha Lifetech can provide CD275/B7-H2/ICOSL corresponding products and help each customer's research and development. In addition, Alpha Lifetech can provide recombinant proteins and Biosimilar antibody products. The effectiveness of the products has been verified through spot products, and we also provide corresponding customized services to help our client companies efficiently and accurately screen corresponding targets through efficient and accurate EC50/IC50. At the same time, Alpha Lifetech also provides services such as recombinant antibody production, recombinant protein production, antibody and protein purification, and affinity verification to ensure the maturity of recombinant antibody affinity and assist customers in antibody drug discovery and subsequent experiments.