B7-H3 (also known as CD 276) is a member of the B7 family of immune checkpoint proteins, highly expressed in cancer cells and activated tumor-infiltrating immune cells, and helps cancer cells evade surveillance by cytotoxic T cells and natural killer cells. There is evidence that B7-H3 is involved in tumor proliferation, metastasis, and treatment resistance, leading to a poor prognosis in patients. CD276 has a dual role in the immune system, both as a co-stimulatory molecule to promote T cell activation and as a co-inhibitory molecule to inhibit T cell function. CD276 mainly acts as a T cell inhibitory molecule to promote tumor proliferation and infiltration, and its upregulated expression can promote the immune escape of tumor cells while reducing the secretion of IFN- γ, TNF- α, and other cytokines. CD276 plays an important role in the development and development of tumors, such as promoting tumor migration and invasion, anti-apoptosis, cell viability, chemotherapy resistance, and epithelial and mesenchymal transformation (EMT). Studies have reported that CD276 can promote the glucose uptake of tumor cells and glycolysis without oxygen conditions, and is also involved in the metastasis of tumor cells.

At present, various drugs targeting CD276/B7-H3 are constantly under development, and taking drugs alone or together with other products to treat diseases has become a new method and remarkable achievements have been made. CD276/B7-H3 protein has shown important research value and application prospects in tumor biology, and drug research and development. With further research and technological advances, CD276/B7-H3 protein products are also essential. Alpha Lifetech can provide CD276/B7-H3 corresponding products and help each customer's research and development. In addition, Alpha Lifetech can provide recombinant proteins and Biosimilar antibody products. The effectiveness of the products has been verified through spot products, and we also provide corresponding customized services to help our client companies efficiently and accurately screen corresponding targets through efficient and accurate EC50/IC50. At the same time, Alpha Lifetech also provides services such as recombinant antibody production, recombinant protein production, antibody and protein purification, and affinity verification to ensure the maturity of recombinant antibody affinity and assist customers in antibody drug discovery and subsequent experiments.