CD326/EpCAM
Alpha Lifetech can provide CD326/EpCAM corresponding products, help each customer's research and development.
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Introduction To CD326/EpCAM
Drug targets a biomolecule that can directly bind to drugs and then react. Generally, the target refers to a protein, which is related to the cause of disease. The focus of the target began with focusing on tumors and then began to spread to various fields. Introduction to CD326/EpCAM protein is a common target in medicine.
Epcam (epithelial cell adhesion molecule, also known as CD326, encoded by tumor-associated calcium signaling 1 gene, belongs to GA733 protein family, is a type I transmembrane glycoprotein and isotype Ca 2 + independent cell adhesion molecule, molecular weight 33 ~ 40 kDa, composed of extracellular domain, single transmembrane domain, intracellular domain, EpEX contains an epidermal growth factor-like repeat domain and a thyroglobulin-like repeat domain, is the structural basis of adhesion between isotype molecules. It is expressed at low levels in the basement membrane of a variety of normal epithelial cells (the highest level in the colon), but it is widely expressed on the cancer cell membrane, especially in squamous carcinoma and adenocarcinoma.
Function of Target CD326/EpCAM
Epcam is involved in cell adhesion processes, but its adhesion is weaker than calcium adhesins. EpCAM is a very classic marker of CSCs (cancer stem cells). Tumor cells expressing EpCAM show greater cancerous ability, and greater stem cell properties. EpCAM is involved in tumor immune regulation, and some scientists have inferred that liver cancer with high EpCAM content can resist NK cell-mediated cytotoxic effects through upregulating carcinoembryonic antigen-related cell adhesion molecule 1. Overexpression of CD326 may lead to uncontrolled cell proliferation and enhanced migratory capacity, thus participating in tumorigenesis and progression.
Gene Pathway of Target CD326/EpCAM
EPCAM interacts with two claudin-7 and cLaudin-1 molecules to regulate the function of tight junctions by preventing their degradation. When the EPCAM gene is knocked down, both claudin-7 and claudin-1 are reduced, tight junctions increase and cells are less susceptible to lysis, demonstrating that EpCAM plays an important role in tumor invasion and dissemination. CD326 may activate the proliferative signaling pathway and promote cell proliferation and division by inducing the expression of genes such as c-myc, cyclins A and E. Abnormalities of this signaling pathway may lead to uncontrolled cell proliferation and tumorigenesis.
Fig 1: EpCAM Gene Pathway. (Reference source: Macdonald J, Henri J, Roy K, Hays E, Bauer M, Veedu RN, Pouliot N, Shigdar S. EpCAM Immunotherapy versus Specific Targeted Delivery of Drugs. Cancers (Basel). 2018 Jan 12;10(1):19.)
Alpha Lifetech Can Provide
At present, various drugs targeting CD326/EpCAM are constantly under development, and taking drugs alone or together with other products to treat diseases has become a new method and remarkable achievements have been made. CD326/EpCAM protein has shown important research value and application prospects in tumor biology, and drug research and development. With further research and technological advances, CD326/EpCAM protein products are also essential. Alpha Lifetech can provide CD326/EpCAM corresponding products and help each customer's research and development. In addition, Alpha Lifetech can provide recombinant proteins and Biosimilar antibody products. The effectiveness of the products has been verified through spot products, and we also provide corresponding customized services to help our client companies efficiently and accurately screen corresponding targets through efficient and accurate EC50/IC50. At the same time, Alpha Lifetech also provides services such as recombinant antibody production, recombinant protein production, antibody and protein purification, and affinity verification to ensure the maturity of recombinant antibody affinity and assist customers in antibody drug discovery and subsequent experiments.
| Catalog Number | Product Name | Product Sizes |
|---|---|---|
| ALP64542 | 50ug,100ug,500ug | |
Reference
[1] Schmelzer E, Pietrosi G, Gridelli B, Gerlach J. Characterization of CD326-positive human hepatic stem cells. Clin Exp Hepatol. 2021 Mar;7(1):101-110.
[2] Baeuerle PA, Gires O. EpCAM (CD326) finding its role in cancer. Br J Cancer. 2007 Feb 12;96(3):417-23.
[3] Ni J, Cozzi PJ, Duan W, Shigdar S, Graham PH, John KH, Li Y. Role of the EpCAM (CD326) in prostate cancer metastasis and progression. Cancer Metastasis Rev. 2012 Dec;31(3-4):779-91.
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2018-07-16
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