CD38 is not only active as a receptor molecule, but also as cyclase and hydrolase, and is a multifunctional protein. It is widely expressed on the surface of immune cells, such as lymphocytes and monocytes, and is involved in cell-to-cell signaling. CD38 uses NAD + as a substrate to form nucleotide metabolites such as the circular ADP ribose (cADPR). These metabolites are potent second messengers capable of regulating Ca 2 + mobilization in the cytoplasm, thereby activating signaling pathways that control various biological processes. This enzymatic activity of CD38 is important for maintaining the dynamic balance of NAD +, nicotinamide, and other substances in vivo. CD38 plays a key role in the activation, proliferation, and apoptosis of immune cells.

CD38 regulates the mobilization of Ca 2 + in the cytoplasm by generating nucleotide metabolites such as cADPR. As an important second messenger, Ca 2 + participates in various cell biological processes, such as cell proliferation, differentiation, apoptosis, etc. During immune cell activation, CD38 synergizes with TCR or other receptors to influence immune cell activation and function by modulating the strength and direction of signaling. CD38 is highly expressed in immunosuppressive cells such as regulatory T cells and regulatory B cells, and participates in the maintenance of immune tolerance by the secretion of immunosuppressive cytokines such as IL-10 and inhibiting the activity and function of TGF- β. In the tumor microenvironment, CD38 participates in the immune escape process of tumors by promoting the formation of an immunosuppressive environment and inhibiting the activity of immune cells. Immunotherapeutic strategies targeting CD38 aim to relieve this immunosuppression and restore the antitumor activity of immune cells.

At present, various drugs targeting CD38 are constantly under development, and taking drugs alone or together with other products to treat diseases has become a new method and remarkable achievements have been made. CD38 protein has shown important research value and application prospects in tumor biology, and drug research and development. With further research and technological advances, CD38 protein products are also essential. Alpha Lifetech can provide CD38 corresponding products and help each customer's research and development. Alpha Lifetech focuses on high-precision detection development and validation services to support drug screening and biosimilar discovery. Our detection methods, including ELISA, cell-based functional testing, and flow cytometry, have undergone rigorous sensitivity, specificity, and reproducibility testing. In addition to testing and development, our team also provides data analysis, scheme optimization, and cross-species reactivity testing to ensure reliable results.