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ERBB2/HER2/CD340

Alpha Lifetech can provide ERBB2/HER2/CD340 corresponding products, help each customer's research and development.

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Introduction To ERBB2/HER2/CD340

Drug targets a biomolecule that can directly bind to drugs and then react. Generally, the target refers to a protein related to the cause of disease. The focus of the target began with focusing on tumors and then began to spread to various fields. Introduction to ERBB2/HER2/CD340 protein is a common target in medicine.
HER 2, also known as EGFR2 / ERBB2 / CD340, is a tyrosine kinase receptor membrane glycoprotein encoded by the ErbB gene, genetically localized to the chromosome 17q21, the 185 kDa cell membrane receptor encoded by the proto-oncogene ERBB 2. ERBB 2 is a transmembrane receptor protein composed of the extracellular domain, a single hydrophobic transmembrane domain, and an intracellular domain. It is an important member of the epidermal growth factor receptor (EGFR) family, which also includes EGFR (HER-1, erbB-1), HER-3 (erbB-3), and HER-4 (erbB-4), which belong to the tyrosine kinase transmembrane receptor (RTK).

Function of Target ERBB2/HER2/CD340

The role of HER 2 is to provide the cells with normal signals for growth and division. However, in some cancers, the HER 2 gene is abnormal, leading to the overexpression of the HER 2 protein, which makes the cancer cells lose their normal growth and division control, and then triggers the occurrence and development of cancer. HER 2 is also an important target target, and through specific targeted therapy targeting HER 2 overexpression, it can effectively inhibit the growth and spread of cancer cells and achieve the therapeutic effect of treating cancer. After binding to ligands such as growth factors on the cell surface, HER 2 promotes cell growth and differentiation by activating downstream signaling pathways.

Gene Pathway of Target ERBB2/HER2/CD340

ERBB 2 can activate downstream signaling by forming homo-or heterodimers with other EGFR family members. The intracellular signaling pathways mediated by HER 2 mainly include MAPK and PI3K / AKT pathways, and the key molecular markers on these signaling pathways include AKT, BRAF, KRAS, HRAS, NRAS, MEK 1, PI3K, and PTEN. After HER 2 activation, the Ras / Raf / MEK / ERK-MAPK pathway is involved in various biological processes, including cell proliferation, differentiation, and migration. The PI3K / Akt / mTOR pathway mainly regulates cell survival, metabolism, and cell cycle progression.
ERBB2
Fig 1: ERBB2 Gene Pathway. (Reference source: Carmona FJ, Montemurro F, Kannan S, Rossi V, Verma C, Baselga J, Scaltriti M. AKT signaling in ERBB2-amplified breast cancer. Pharmacol Ther. 2016 Feb;158:63-70.)

Alpha Lifetech Can Provide

At present, various drugs targeting ERBB2/HER2/CD340 are constantly under development, and taking drugs alone or together with other products to treat diseases has become a new method and remarkable achievements have been made. ERBB2/HER2/CD340 protein has shown important research value and application prospects in tumor biology, and drug research and development. With further research and technological advances, ERBB2/HER2/CD340 protein products are also essential. Alpha Lifetech can provide ERBB2/HER2/CD340 corresponding products and help each customer's research and development. Alpha Lifetech focuses on high-precision detection development and validation services to support drug screening and biosimilar discovery. Our detection methods, including ELISA, cell-based functional testing, and flow cytometry, have undergone rigorous sensitivity, specificity, and reproducibility testing. In addition to testing and development, our team also provides data analysis, scheme optimization, and cross-species reactivity testing to ensure reliable results.

Reference 

[1] Iqbal N, Iqbal N. Human Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic Implications. Mol Biol Int. 2014;2014:852748.    
[2] Shirman Y, Lubovsky S, Shai A. HER2-Low Breast Cancer: Current Landscape and Future Prospects. Breast Cancer (Dove Med Press). 2023 Aug 14;15:605-616. 
[3] Klocker EV, Suppan C. Biomarkers in Her2- Positive Disease. Breast Care (Basel). 2020 Dec;15(6):586-593. 

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