Galectin-9/Gal-9/Lgals9
Alpha Lifetech can provide Galectin-9/Gal-9/Lgals9 corresponding products, help each customer's research and development.
01
Introduction To Galectin-9/Gal-9/Lgals9
Drug targets a biomolecule that can directly bind to drugs and then react. Generally, the target refers to a protein related to the cause of disease. The focus of the target began with focusing on tumors and then began to spread to various fields. Introduction to Galectin-9/Gal-9/Lgals9 protein is a common target in medicine.
Galectin-9 belongs to the Galectin protein family and is a subset of lectins with a carbohydrate recognition domain, Galectin-9 is a tandem protein, composed of two carbohydrate recognition domains connected by junction sequences, and can crosslink glycoproteins, forms a multivalent lattice, the absence of Galectin-9 is associated with the occurrence and development of many solid tumors, such as breast cancer, gastric cancer, hepatocellular carcinoma and cholangiocyte carcinoma.
Function of Target Galectin-9/Gal-9/Lgals9
Like other Galectins, Galectin-9 has a variety of biological regulatory functions, including the proliferation, adhesion, aggregation, and apoptosis of tumor cells. By binding to receptors such as Tim-3, Galectin-9 can induce the apoptosis of T cells, thereby inhibiting the activation and proliferation of T cells. Galectin-9 can induce apoptosis in various cell types, including T cells, tumor cells, etc. By promoting apoptosis, Gal-9 plays a role in clearing damaged cells, maintaining tissue homeostasis, and inhibiting tumor growth. The al-9 has adhesive activity and can promote cell – cell interactions or between cells and the extracellular matrix. This adhesive action is important in processes such as embryonic development, tissue repair, and tumor invasion. In the tumor microenvironment, the expression of Gal-9 is often up-regulated, inhibiting the activity of anti-tumor T cells, thus helping tumor cells escape immune surveillance and clearance. Moreover, Gal-9 may also promote tumor progression by promoting angiogenesis and enhancing the migration and invasion capacity of tumor cells.
Gene Pathway of Target Galectin-9/Gal-9/Lgals9
PD-1 interacts with Gal-9 and TIM-3 to attenuate Gal-9 / TIM-3-induced apoptosis of PD-1 + TIM-3 + T cells, Gal-9 is upregulated by inflammatory cytokines IFN β and γ, and targeting Gal-9 is an effective strategy for cancer immunotherapy. After Gal-9 binds to Tim-3, it can induce the apoptosis of T cells, thus inhibiting the immune response of T cells. This signaling pathway plays an important role in the induction of immune tolerance, the prevention and treatment of autoimmune diseases, and tumor immunotherapy. It was found that PD-1, by binding to Gal-9, contributes to the persistence of PD-1 + TIM-3 + T cells and attenuates cell death in Gal-9 / Tim-3-induced cells. This synergy reveals a critical role of PD-1 in the survival of depleted T cells and establishes Gal-9 as an important regulator of the tumor immune response.
Fig 1: Gal-9 Gene Pathway. (Reference source: Yu J, Zhu R, Yu K, Wang Y, Ding Y, Zhong Y, Zeng Q. Galectin-9: A Suppressor of Atherosclerosis? Front Immunol. 2020 Nov 4;11:604265.)
Alpha Lifetech Can Provide
At present, various drugs targeting Galectin-9/Gal-9/Lgals9 are constantly under development, and taking drugs alone or together with other products to treat diseases has become a new method and remarkable achievements have been made. Galectin-9/Gal-9/Lgals9 protein has shown important research value and application prospects in tumor biology, and drug research and development. With further research and technological advances, Galectin-9/Gal-9/Lgals9 protein products are also essential. Alpha Lifetech can provide Galectin-9/Gal-9/Lgals9 with corresponding products and help each customer's research and development. Alpha Lifetech provides end-to-end biotechnology development solutions, from upstream cell culture optimization to downstream purification scale. Our process is validated through analytical techniques such as HPLC, SDS-PAGE, and mass spectrometry to ensure product consistency and regulatory compliance. By combining cutting-edge biotechnology expertise with flexible service models, we help clients accelerate project research progress and ensure smooth experimentation.
| Catalog Number | Product Name | Product Sizes |
|---|---|---|
| ALP64661 | 50ug,100ug,500ug | |
| ALP64595 | ALP64595-Recombinant Mouse Galectin-9/Gal-9/Lgals9 Protein, GST Tag | 50ug,100ug,500ug |
Reference
[1] Yang R, Sun L, Li CF, Wang YH, Yao J, Li H, Yan M, Chang WC, Hsu JM, Cha JH, Hsu JL, Chou CW, Sun X, Deng Y, Chou CK, Yu D, Hung MC. Galectin-9 interacts with PD-1 and TIM-3 to regulate T-cell death and is a target for cancer immunotherapy. Nat Commun. 2021 Feb 5;12(1):832.
[2] Lv R, Bao Q, Li Y. Regulation of M1‑type and M2‑type macrophage polarization in RAW264.7 cells by Galectin‑9. Mol Med Rep. 2017 Dec;16(6):9111-9119.
[3] Rezaei M, Ghanadian M, Ghezelbash B, Shokouhi A, Bazhin AV, Zamyatnin AA Jr, Ganjalikhani-Hakemi M. TIM-3/Gal-9 interaction affects glucose and lipid metabolism in acute myeloid leukemia cell lines. Front Immunol. 2023 Nov 10;14:1267578.
Video Resources
If you have any questions, please feel free to contact us at any time.
Leave Your Message
2018-07-16
0102