Ka lawelawe hana ʻana i nā antibody Chemiric
Hāʻawi ʻo Alpha Lifetech i kahi ākea o nā lawelawe kūikawā, me ka hoʻopili ʻana o ka antibody humanization, ka hōʻike ʻana o ka antibody chimeric piha.
KĀHEA IĀ MĀ˚OUKa lawelawe hana ʻana i nā antibody Chemiric
Ma ke ʻano he hoʻokahi o nā mea hana bio-ʻoihana,ʻO Alpha Lifetech Inc.ke lilo nei i loea i ke kahua o ka ʻenekinia antibody. Hāʻawi mākou i kahi ākea o nā lawelawe kūikawā, me ka hoʻokumu ʻana i ka antibody humanization, ka hōʻike ʻana o nā antibodies chimeric piha piha, a me ka hana nui ʻana o nā antibodies domain hoʻokahi (sdAbs).
ʻO Alpha Lifetech Inc.ua hoʻomohala i kahi hoʻolālā ponoʻī no ka hana wikiwiki ʻana o nā antibodies chimeric e komo pū ana me ka ʻiole/kanaka piha, ʻiole/kanaka, ʻiole/lāpaki, ʻiole/lāpaki, a me nā antibodies hybrid ʻē aʻe. ʻO kā mākou ʻenehana antibody chimeric ponoʻī e hiki ai iā ʻoe ke kuhikuhi i kāu mau koi no ka hōʻike ʻana a me ke ʻano. Loaʻa i kā mākou poʻe ʻepekema ka ʻike nui i ke kūkulu ʻana a me ka hōʻike ʻana i nā antibodies recombinant a chimeric paha o nā isotypes like ʻole, me nā ʻāpana mau i hoʻololi ʻia. Hoʻomaʻamaʻa pū mākou i ka hōʻike ʻana i nā cell mammalian me ka hoʻohana ʻana i kā mākou ʻōnaehana hōʻike mammalian recombinant.
Hoʻolauna i ka Antibody Chimeric
ʻO nā antibodies Chimeric he mau antibodies e hoʻohui i nā ʻāpana loli antibody makua a me kekahi wahi kūpaʻa acceptor. ʻAʻole hoʻopilikia ka Chimerization i ka antibody specificity a i ʻole ka affinity ma muli o ke ʻano o ka hoʻonohonoho ʻana o nā antibodies. Mālama nā antibodies Chimeric i ka antigen specificity a me ka affinity o ka antibody makua akā hōʻike i kahi hapalua ola lōʻihi a me ka hiki ke hoʻoponopono i nā pane CDC a me ADCC.
ʻO ka antibody chimeric (cAb) he antibody i hana ʻia ma ka hoʻohui ʻana i ka ʻāpana hoʻopaʻa antigen (nā kikowaena loli o nā kaulahao kaumaha a me ka māmā, VH a me VL) mai kekahi ʻano e like me ka ʻiole, me ka kikowaena mau (ʻāpana effector) mai kekahi ʻano ʻē aʻe e like me ka lāpaki. Mālama nā antibodies Chimeric i ke ʻano kūikawā o ka antigen a me ka pili o ka antibody mua akā e hōʻemi i ka pilikia o ka pane ʻana i nā antibodies haole mai kahi kumu ʻaʻole SELF ke hoʻohana ʻia i loko o ke keʻena lapaʻau. He mau mea hana waiwai nā antibodies chimeric no ka noiʻi in vitro a me in vivo.
ʻAʻohe kapu i nā ʻano antibody
ʻAe nā antibodies Chimeric i ka antibody e hoʻopilikino ʻia i kahi noi kikoʻī me ka ʻole o ka palena ʻia e nā ʻano antibody mua.
Hoʻololi i kekahi kahua
Hiki i nā antibodies Chimeric ke hoʻololi maʻalahi i nā mea noiʻi i kā lākou mau antibodies monoclonal i koho ʻia i kekahi kahua me ka mālama ʻana i ke ʻano kikoʻī a me ka ʻike o nā antibodies mua i nā antigens kikoʻī.
ʻO ke kahe ʻana o ka cytometry a me IHC
Hiki i nā antibodies Chimeric ke pale aku i nā pilikia hoʻopaʻa pili ʻole e pili ana me ka hoʻopaʻa ʻana o ka antibody lua i ke kelepona hoʻāʻo a i ʻole ka ʻiʻo (kahi pilikia maʻamau no ka cytometry kahe a me IHC).
Hoʻokumu ʻana i ka antibody
ʻO ka antibody chimerism kahi hana mua ma mua o ka antibody humanization, e manaʻo ana e hoʻopili i nā hana olaola me nā antibodies makua a me ka hoʻēmi ʻana i ko lākou immunogenicity. Ma kekahi ʻaoʻao, hiki ke hoʻohana ʻia nā antibodies chimeric no nā kumu therapeutic i nā maʻi kikoʻī a i ʻole kekahi mau kūlana (me nā kikowaena loli GI kiʻekiʻe).
nā kumu hōʻoia
ʻO nā antibodies Chimeric ka mea pani maikaʻi loa no ke serum, nā kūlana calibration, a me nā kaohi maikaʻi i ka nānā ʻana i ka diagnostic. He kūpono loa lākou no ka mea hiki ke hana ʻia i nā nui palena ʻole a he like (e mālama ana i ka antibody specificity a me ka affinity).
ka hoʻomohala ʻana i ka hoʻāʻo
E hoʻohana ma ke ʻano he calibrators (standards) a i ʻole nā mana i nā immunoassays - Ua hoʻolālā ʻia nā immunoassays serological e ʻike i kahi antibody kikoʻī i nā laʻana maʻi e hilinaʻi nei i nā serum calibrators (standards) a i ʻole nā mana maikaʻi.
2018-07-16 
