IL1B
Alpha Lifetech can provide IL1B corresponding products, help each customer's research and development.
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Introduction To IL1B
Drug targets a biomolecule that can directly bind to drugs and then react. Generally, the target refers to a protein, which is related to the cause of disease. The focus of the target began with focusing on tumors and then began to spread to various fields. Introduction to IL1B protein is a common target in medicine.
Interleukin 1β (IL-1β) encoded by the IL 1B gene is one of the most prominent cytokines. As an important member of the IL-1 family, the IL1B genome is 7.8 kb, located on the long arm of chromosome 2, and contains 7 exons. It is usually produced by monocytes and macrophages, in addition, almost all nucleated cells, such as B cells, NK cells, T cells cultured in vitro, keratinocytes, dendritic cells, astrocytes, fibroblasts, neutrophils, endothelial cells, and smooth muscle cells can produce IL-1β.
Function of Target IL1B
IL 1B Is an inflammatory cytokine located upstream of the cytokine cascade, is widely believed to be required for efficient initiation of innate immunity and formation of an adaptive immune response to resolve acute inflammation, and is an amplifier of the immune response. It is also a central mediator of cell-cell interactions in the inflammatory tumor microenvironment. IL 1B has the function of regulating immune cells such as dendritic cells, macrophages, and Th 2 cells, and its aggregation in local tissues; promotes the differentiation of Th 17 cells and related factors; promotes eosinophil degranulation, enhances its cytotoxic effects and induced inflammatory reactions. Increase the synthesis, expression, and release of various cytokines and adhesion factors, including IL-18, intercellular adhesion molecules, vascular cell adhesion molecules, E-selectin, etc. An important role in the fibrotic process of local tissues.
Gene Pathway of Target IL1B
The pro-inflammatory cytokine IL 1 B inhibits gastrin expression by activating Smad 7 and subsequently suppresses the nuclear localization of the Smad 3 / 4 complex. A polymorphic promoter variant of the IL 1 B gene can regulate IL 1 B expression, differentially activating Smad 7 and subsequent suppression of gastrin expression, respectively. After IL 1B binds to receptors on target cells, it activates the IL-1 signaling pathway and myeloid differentiation factor-dependent NF- κ B pathway and exerts positive feedback effects to promote transcription of pro-inflammatory cytokines, induce inflammatory response, and cause fever in the body.
Fig 1: IL-1B Gene Pathway. (Reference source: Tulotta C, Ottewell P. The role of IL-1B in breast cancer bone metastasis. Endocr Relat Cancer. 2018 Jul;25(7): R421-R434.)
Alpha Lifetech Can Provide
At present, various drugs targeting IL1B are constantly under development, and taking drugs alone or together with other products to treat diseases has become a new method and remarkable achievements have been made.IL1B has shown important research value and application prospects in tumor biology, and drug research and development. With further research and technological advances, IL1B products are also essential. Alpha Lifetech can provide IL1B with corresponding products and help each customer's research and development. Alpha Lifetech focuses on high-precision detection development and validation services to support drug screening and biosimilar discovery. Our detection methods, including ELISA, cell-based functional testing, and flow cytometry, have undergone rigorous sensitivity, specificity, and reproducibility testing. In addition to testing and development, our team also provides data analysis, scheme optimization, and cross-species reactivity testing to ensure reliable results.
| Catalog Number | Product Name | Product Sizes |
|---|---|---|
| ADT1379 | 1mg,5mg | |
| ADT1114 | ADT1114-Canakinumab Biosimilar-Anti IL1B mAb- Research Grade | 1mg,5mg |
| ADT1275 | ADT1275-Gevokizumab Biosimilar-Anti IL1B mAb- Research Grade | 100ug,1mg,5mg |
| ADT1086 | ADT1086-Bermekimab Biosimilar-Anti IL1A mAb- Research Grade | 100ug,1mg,5mg |
Reference
[1] Rawat M, Nighot M, Al-Sadi R, Gupta Y, Viszwapriya D, Yochum G, Koltun W, Ma TY. IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA. Gastroenterology. 2020 Oct;159(4):1375-1389.
[2] Harati-Sadegh M, Sargazi S, Khorasani M, Ansari-Moghaddam A, Mirinejad S, Sheervalilou R, Saravani R. IL1A and IL1B gene polymorphisms and keratoconus susceptibility: evidence from an updated meta-analysis. Ophthalmic Genet. 2021 Oct;42(5):503-513.
[3] Zhang D, Duan S, He Z, Zhu Z, Li Z, Yi Q, Cai T, Li J, Chen N, Guo S. Sijunzi Decoction Targets IL1B and TNF to Reduce Neutrophil Extracellular Traps (NETs) in Ulcerative Colitis: Evidence from Silicon Prediction and Experiment Validation. Drug Des Devel Ther. 2023 Oct 17;17:3103-3128.
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2018-07-16
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