IL5 and IL5R
Alpha Lifetech can provide IL5 and IL5R corresponding products, help each customer's research and development.
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Introduction To IL5 and IL5R
Drug targets a biomolecule that can directly bind to drugs and then react. Generally, the target refers to a protein related to the cause of disease. The focus of the target began with focusing on tumors and then began to spread to various fields. Introduction to IL5 and IL5R protein is a common target in medicine.
IL-5 is a pleiotropic cytokine, also known as T cell replacement factor, acidophil colony-stimulating factor 1, acidophil differentiation factor, etc. IL5 is mainly secreted and expressed by T2 lymphocytes Th2, innate lymphocytes ILC2, mast cells, and oncocytes. IL-5R consists of the specific IL-5R α subunits and a non-specific β c heterodimer. IL5 is a dimeric protein with a 4-helical motif that acts on target cells by binding a specific IL5 receptor (IL5R), and though IL5 is a homodimer, it can only bind one IL5R receptor molecule, because the IL5R binding site on IL5 extends to intramolecular sides of the dimer, and IL5R three Fn III domains surround the ligand IL-5, like a wrench around a nut, this wrench-like structure increases the interaction surface area between the receptor and the ligand.
Function of Target IL5 and IL5R
IL 5 is mainly secreted by T cells, these cells in inhaled allergens, respiratory viruses airborne pollutants, and other environmental stimuli release IL 5, at the same time IL 5 has a pleiotropic effect on eosinophils, promotes their maturation, activation, survival, migration from the blood and into the respiratory tract, is a powerful pro-inflammatory cytokine. Therefore, IL-5 is the major cytokine affecting the growth, differentiation, recruitment, activation, and survival of eosinophils, and plays a key role in the pathophysiology of eosinophil-enhancing asthma. Its biological effects are mediated through a selective interaction with its receptor, IL-5R.
Gene Pathway of Target IL5 and IL5R
The IL5 receptor is composed of the IL5 receptor α subunit (IL5R α) and the co-receptor β c subunit (the β c subunit is a signal transduction molecule). IL5R α specifically binds IL5, inducing β c recruitment to IL5R, shared with two monomeric cytokine receptors IL3 and granulocyte-macrophage colony-stimulating factor (GM-CSF), and subsequently activates a complex intracellular signaling network composed of JAK 1 / 2-STT 1 / 3 / 5 module, P38 and MAP kinase and NF-ᴋB transcription factors, ultimately leading to eosinophil maturation, survival, and activation.
Fig 1: IL-5 Gene Pathway. (Reference source: Pelaia C, Paoletti G, Puggioni F, Racca F, Pelaia G, Canonica GW, Heffler E. Interleukin-5 in the Pathophysiology of Severe Asthma. Front Physiol. 2019 Dec 17;10:1514.)
Alpha Lifetech Can Provide
Currently, various immune drugs targeting IL5 and IL5R targets are in the updating iteration, and taking the disease alone or in combination with other products has become a new approach with remarkable achievements. The IL5 and IL5R targets have shown important research value and application prospects in both biology and drug research and development. With further research and detection technology advances, IL5 and IL5R target products are also essential in medical research.Alpha Lifetech can provide IL5 and IL5R corresponding products and help each customer's research and development. Alpha Lifetech focuses on high-precision detection development and validation services to support drug screening and biosimilar discovery. Our detection methods, including ELISA, cell-based functional testing, and flow cytometry, have undergone rigorous sensitivity, specificity, and reproducibility testing. In addition to testing and development, our team also provides data analysis, scheme optimization, and cross-species reactivity testing to ensure reliable results.
| Catalog Number | Product Name | Product Sizes |
|---|---|---|
| ADT1168 | 100ug,1mg,5mg | |
| ADT1392 | ADT1392-Mepolizumab Biosimilar-Anti IL5 mAb- Research Grade | 1mg,5mg |
| ADT1546 | ADT1546-Reslizumab Biosimilar-Anti IL5 mAb- Research Grade | 1mg,5mg |
| ADT1082 | ADT1082-Benralizumab Biosimilar-Anti IL5RA/CD12 mAb- Research Grade | 1mg,5mg |
Reference
[1] Pelaia C, Paoletti G, Puggioni F, Racca F, Pelaia G, Canonica GW, Heffler E. Interleukin-5 in the Pathophysiology of Severe Asthma. Front Physiol. 2019 Dec 17;10:1514.
[2] Takatsu K. Interleukin 5 and B cell differentiation. Cytokine Growth Factor Rev. 1998 Mar;9(1):25-35.
[3] Bachmann MF, El-Turabi A, Fettelschoss-Gabriel A, Vogel M. The Prospects of an Active Vaccine Against Asthma Targeting IL-5. Front Microbiol. 2018 Oct 24;9:2522.
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2018-07-16
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