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Pūhara Whakawhanake Paturopi Takirua

Ka taea e Alpha Lifetech te whakarato ki ngā kiritaki he hua me ngā ratonga kimi paturopi me te pūmua hangarua kounga kua whakapūmautia.

Tonohia he Tāpaetanga
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Pūhara Whakawhanake Paturopi Takirua

Ka taea e Alpha Lifetech te whakarato ki ngā kiritaki he hua me ngā ratonga kimi paturopi me te pūmua recombinant kua whakapūmautia te kounga. Ka taea e mātou te whakarite i ngā paturopi me te whai huatanga teitei, te motuhaketanga kaha, me te pumau pai. He maha ngā taputapu me ngā taputapu purenga paturopi a Alpha Lifetech, e taea ai te whakarato ratonga purenga paturopi mai i ngā momo puna pēnei i te rāpeti, hipi, heihei, me te kiore monoclonal paturopi, tae atu ki ngā ratonga purenga hononga Protein A/G me ngā ratonga wehewehe me te purenga paturopi. I runga i te hanganga pūnaha tūāpapa whānui o te tūāpapa kitenga paturopi, te tūāpapa pūmua, me ētahi atu, ka hipokina e mātou ngā ratonga whakarunga me te whakararo o te hanga paturopi, ā, ka taea te whakarato ratonga hangarau mai i te whakarite paturopi, te purenga paturopi takirua me te wehenga me te purenga paturopi, te raupapatanga paturopi, te whakamana paturopi, me ētahi atu, ka taea te whakamahi mō te rongoā paturopi takirua.

Ko ngā paturopi monoclonal e pā ana ki ngā immunoglobulin i hangaia e te pūtau B kotahi he tino motuhake mō ngā antigens, ngā epitopes rānei. I te tuatahi i whakaritea te hanga paturopi monoclonal mā te whakamahi i te hangarau hybridoma hei hanga paturopi kiore. Ina koa, mā te whakakotahi i ngā pūtau whēkau mai i ngā kiore kua werohia ki ngā pūtau myeloma mai i te tangata, i ngā kiore rānei, ka hangaia ngā pūtau hybridoma, e huna ana i ngā paturopi motuhake. Ko ngā paturopi monoclonal kiore i hangaia ka whakamahia nuitia i roto i te rangahau kararehe me te tātaritanga mate i muri i ngā ratonga purenga. Heoi, ka whakaputa te tinana tangata i tētahi urupare ārai mate ki ngā pūmua kiore ke, nō reira he nui ngā herenga i roto i te tono haumanu o te hanga paturopi monoclonal kiore. I muri mai, i whakamahia e te tangata te "whakatangata tangata" hei whakarite i ngā paturopi monoclonal mai i ngā kiore, ā, i whakamahia te hangarau hangarau ira hei whakarerekē i ngā paturopi kiore kia mau tonu te rohe o te immunoglobulin tangata hei whakaiti i tō rātou ārai mate. E mōhiotia ana hoki tēnei momo paturopi ko te paturopi monoclonal tangata. Hei tāpiri, ko te whakamahi i ngā pūtau tangata hei hanga paturopi monoclonal ka kiia ko te whakarite paturopi monoclonal tangata katoa. He whānui te whakamahinga o ngā paturopi monoclonal i roto i ngā tono hauora me te haumanu. I roto i ngā rangahau hauora, ka taea te whakamahi i ngā paturopi monoclonal hei ārai mate, ka taea te whakamahi i ngā paturopi monoclonal rongoā mō te chemotherapy mate pukupuku me te maimoatanga mate huaketo, ā, ko te whanaketanga o ngā hononga paturopi monoclonal e whakamahia ana mō te maimoatanga mate pukupuku.

He Kupu Whakataki ki te Paturopi Takirua

I te tau 1960, i whakaarohia te ariā o ngā paturopi takirua. Ko ngā paturopi takirua, e mōhiotia ana ko ngā paturopi takirua, he paturopi hangai mā te whakamahi i te hangarau hangarau ira. Hei paturopi hangai kua hangaia, ko ngā paturopi takirua nō te akomanga IgG, ā, kei roto he wāhanga here antigen e aro ana ki te wae CD3. E rua ngā pae here antigen motuhake o ngā paturopi takirua ka taea te here me te mōhio i ngā antigen rerekē e rua i te wā kotahi, i ngā epitope rerekē rānei e rua o te antigen. Ki te whakatauritea ki ngā paturopi takirua, he pae here antigen motuhake anō ō ngā paturopi takirua, nō reira he kaha ake te motuhaketanga me te kaha ki te arotahi, ka taea te arotahi tika ake i ngā pūtau pukupuku me te whakaiti i te paitini i waho o te ūnga. Ka taea e ngā paturopi takirua te mahi i ngā mahi koiora maha i te wā kotahi, pērā i te kimi i ngā pūtau ārai mate, te aukati i ngā ara tohu, me te patu tika i ngā pūtau pukupuku. Ko ngā paturopi takirua o mua i whakaritea mā te whakakotahitanga matū, te whakakotahitanga pūtau rānei, engari tera pea kua puhoi te haere o tēnei tikanga nā te whakakotahitanga matapōkere me te uaua ki te wehe i te huinga ūnga. I te whanaketanga tonu o te hangarau hangarau ira, he maha ngā tūāpapa hangarau hou kua whakawhanakehia, pērā i ngā knots in holes (KIH), CrossMab, DVD Ig, me ētahi atu. Ka whakaoti pai ēnei tūāpapa i ngā raruraru pērā i te kore taurite o ngā mekameka taumaha me ngā mekameka māmā, ā, ka whakapai ake i te ōritetanga me te hua o ngā paturopi takirua.
bsAbs
Pikitia 1. He tirohanga whānui ngāwari mō ngā tikanga mahi kua whakaarohia mō ngā paturopi takirua (bsAbs) i roto i ngā whakamātautau haumanu mō te mate pukupuku.(Pūtake o te pikitia: He arotake i ngā paturopi takirua me ngā hanganga paturopi i roto i ngā wero matepukupuku me te haumanu - ScienceDirect)

Hangarau Whakaputa Paturopi Takirua

Ko ngā tikanga matua mō te whakaputa paturopi takirua ko te hononga matū, te hybridoma pūtake whā, me te whakarite paturopi hangarau ira. I roto i ēnei, ko te tikanga hononga matū e hono ana i ngā IgG e rua, i ngā kongakonga paturopi F (ab ') 2 rānei e rua ki roto i ngā paturopi takirua mā te whakamahi i ngā kaihoko hononga matū pēnei i te phthalimide me te waikawa dithioacylbenzoic. He māmā noa iho tēnei tikanga, ā, he ngāwari ki te whakahaere, engari ka kino pea te pae here antigen, ka whakaiti i te mahi paturopi, ā, he taumata mate pukupuku anō hoki tō te kaihoko hononga. Ko te tikanga hybridoma pūtake whā e hangai ana ki te whakakotahitanga o ngā pūtau somatic mai i ngā raina pūtau hybridoma rerekē e rua hei whakaatu i te IgG kiore e rite ana. Mā te hangarau hangarau ira, ka taea te whakarerekē ira i ngā paturopi hei hanga paturopi takirua. I hangaia ngā paturopi monoclonal rerekē e rua, ā, i wehea motuhaketia ngā kongakonga Fab, ngā rohe mekameka taumaha me ngā mekameka māmā o ngā paturopi e rua. Mā te hangarau tauhohenga hononga-whiti, te hangarau whakakotahi mekameka rānei, i whakakotahihia ngā kongakonga e rua hei hanga paturopi takirua. Ahakoa he tino uaua te hangarau hangarau ira, koinei te tikanga e whakamahia whānuitia ana mō te whakaputa paturopi takirua hei whakatika i te hanganga me te mahi a ngā paturopi. I te wā e whakahaerehia ana te hoahoa paturopi takirua, ka taea te whakamahi i te mātāpono o te tauhohenga whakawhiti paturopi, engari ka puta pea ngā tauhohenga kore-motuhake i te tauhohenga whakawhiti paturopi, nō reira ka ata whakaarohia i roto i te whakamahinga mahi o te hoahoa paturopi takirua, pērā i te rongoā paturopi takirua.

Te Whakamaemaetanga o ngā Paturopi Takirua

Ko te purenga paturopi takirua te tukanga wehe me te purenga o ngā paturopi ūnga parakore-teitei. E rua ngā tikanga, ko te centrifugation me te tātari hohonu, e whakamahia ana hei tango i ētahi poke wairewa. Ka hopukina tuatahitia te paturopi takirua ūnga mā te chromatography hononga. Mō ngā paturopi takirua rite ki te IgG, ka whakamahia te chromatography hononga pūmua A, engari mō ngā paturopi takirua kore-IgG, ka taea te whakamahi i te chromatography hononga mekameka māmā. Muri iho, ka whakatōkia te paturopi i raro i ngā āhuatanga pH iti mō tētahi wā, ka pakaru te hanganga pūmua i runga i te mata o te kōpaki huaketo, ā, ka ngaro te kaha ki te pangia ngā pūtau. Ka mahia te tātari hohonu waenga hei tango atu i ngā poke pērā i ngā pūmua pūtau manaaki (HCP). Ka whakapai ake i te parakore o ngā paturopi mā ngā tikanga pērā i te chromatography whakawhiti katote, ā, ka tangohia ngā huaketo toenga mā ngā tikanga nanofiltration, ultrafiltration rānei. Hei whakamutunga, ka whakaemihia te tauira ka whakakapia ki tētahi arai hanganga e tika ana.

Rerenga Mahi Ratonga Whakaputa Paturopi Takirua

Ngā Hipanga Ihirangi Ratonga Rārangi Wā
Te Hanga Ira
Te whakaputanga o te 3 ngā hoahoa rerekē o ngā raupapatanga, te whakaputanga de novo o ngā plasmid DNA paturopi recombinant
2-3 wiki
Whakamātautau Tauine Iti Te whakaputanga o ngā pūmua paturopi takirua → Te whakaaturanga tauine iti i roto i ngā raina pūtau mammal → Te whakamana mā te SDS-PAGE → Te tātari here me ngā antigens pūmua recombinant mā te ELISA → Te whakataurite i ngā iraira me ngā paturopi mātua 5-6 wiki
Tāutuhia
Te whakapuakitanga o ngā paturopi takirua tuatahi e rua → Te tātari here mā te ELISA → Te aromatawai ELISA o ngā paturopi i kitea e ngā paturopi kiore
1 wiki
Te Hanganga Paturopi
Te whakaputanga paturopi nui
3-4 wiki

Ā Mātou Painga

Ka hipokina e mātou ngā ratonga whakarunga me ngā ratonga whakararo o te hanga paturopi, ā, ka taea e mātou te whakarato ratonga hangarau mai i te whakarite paturopi, te purenga paturopi takirua me te wehenga me te purenga paturopi, te raupapatanga paturopi, te whakamana paturopi, me ētahi atu, ka taea te whakamahi mō te rongoā paturopi takirua.

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    Te Whakapuakitanga Teitei

    Te nui o te whakaputanga pūmua i roto i ngā pūtau CHO.

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    Rokiroki Pūmau

    >2 wiki i roto i te toto i te 37 °C.

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    Kāore he raruraru wairewa

    >30 mg/ml

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    Ngā Waea Pūtau Pūmau

    He maha ngā raina pūtau pumau me ngā antigens pukupuku kua whakawhanakehia hei whakamana i ngā paturopi bispecific maha.

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